Global and local cortical folding alterations are associated with neurodevelopmental subtype in bipolar disorders : a sulcal pits analysis

Article Article scientifique Article Global and local cortical folding alterations are associated with neurodevelopmental subtype in bipolar disorders : a sulcal pits analysis eng 2023-01-04 2023-03-15 author Lefrere Antoine Department of Psychiatry Sainte Marguerite Hospital, Assistance Publique Hôpitaux de Marseille, 13009 Marseille, France; Institut de Neurosciences de la Timone UMR 7289, Aix-Marseille Université & CNRS, Marseille, France; Fondation Fondamental, Créteil, France. author Auzias Guillaume Institut de Neurosciences de la Timone UMR 7289, Aix-Marseille Université & CNRS, Marseille, France. author Favre Pauline Fondation Fondamental, Créteil, France; Paris Saclay University, UNIACT, Eq. Psychiatry, NeuroSpin, CEA Saclay, Gif-sur-Yvette, France; Paris Est University, INSERM U955, Eq. Neuropsychiatrie Translationnelle, Assistance Publique Hôpitaux de Paris, Hôpitaux Universitaires Mondor, DMU IMPACT de Psychiatrie et d'Addictologie, Créteil, France. author Kaltenmark Irène MAP5 Paris Descartes University, France. author Houenou Josselin Fondation Fondamental, Créteil, France; Paris Saclay University, UNIACT, Eq. Psychiatry, NeuroSpin, CEA Saclay, Gif-sur-Yvette, France; Paris Est University, INSERM U955, Eq. Neuropsychiatrie Translationnelle, Assistance Publique Hôpitaux de Paris, Hôpitaux Universitaires Mondor, DMU IMPACT de Psychiatrie et d'Addictologie, Créteil, France. author Piguet Camille Department of Psychiatry, Faculty of Medicine, University of Geneva, Switzerland. 699009 author Polosan Mircea Grenoble Alpes University, Inserm U1216 Grenoble Institute of Neuroscience, CHU Grenoble Alpes, Grenoble, France. author Eyler Lisa T Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA. author Phillips Mary L Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. author Versace Amelia University of Pittsburgh Medical Center, University of Pittsburgh. author Wessa Michèle Department of Clinical Psychology and Neuropsychology, Johannes Gutenberg University, Mainz, Germany. author McDonald Colm Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, H91 TK33, Galway, Ireland. author Cannon Dara M Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, H91 TK33, Galway, Ireland. author Brambilla Paolo Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. author Bellani Marcella Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Italy; UOC of Psychiatry, Azienda Ospedaliera Universitaria Integrata (AOUI) of Verona, Italy. author Deruelle Christine Institut de Neurosciences de la Timone UMR 7289, Aix-Marseille Université & CNRS, Marseille, France. author Belzeaux Raoul Institut de Neurosciences de la Timone UMR 7289, Aix-Marseille Université & CNRS, Marseille, France; Fondation Fondamental, Créteil, France; Pôle Universitaire de Psychiatrie, CHU de Montpellier, France. Electronic address: belzeaux.raoul@gmail.com. 224-230 10.1016/j.jad.2022.12.156 36608853 0165-0327 https://www.sciencedirect.com/science/article/pii/S0165032722015166 Background: Analyzing cortical folding may provide insight into the biological underpinnings of neurodevelopmental diseases. A neurodevelopmental subtype of bipolar disorders (BD-ND) has been characterized by the combination of early age of onset and psychotic features. We investigate potential cortical morphology differences associated with this subtype. We analyze, for the first time in bipolar disorders, the sulcal pits, the deepest points in each fold of the cerebral cortex. Methods: We extracted the sulcal pits from anatomical MRI among 512 participants gathered from 7 scanning sites. We compared the number of sulcal pits in each hemisphere as well as their regional occurrence and depth between the BD-ND subgroup (N = 184), a subgroup without neurodevelopmental features (BD, N = 77) and a group of healthy controls (HC, N = 251). Results: In whole brain analysis, BD-ND group have a higher number of sulcal pits in comparison to the BD group. The local analysis revealed, after correction for multiple testing, a higher occurrence of sulcal pits in the left premotor cortex among the BD-ND subgroup compared to the BD and the HC groups. Conclusion: Our findings confirm that BD-ND is associated with a specific brain morphology revealed by the analysis of sulcal pits. These markers may help to better understand neurodevelopment in mood disorder and stratify patients according to a pathophysiological hypothesis. Bipolar disorder Early onset Imaging Neurodevelopment Premotor Psychosis Humans Bipolar Disorder / diagnostic imaging Cerebral Cortex / diagnostic imaging Brain Magnetic Resonance Imaging Motor Cortex Neurodevelopmental Disorders Dewey 616.89 60 Département de psychiatrie 225 false 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 Journal of affective disorders 325 d3b129b8-bc1a-48fb-b7c0-baa803da0e5f Article (Accepted version) Public glob.pdf 1845220 application/pdf Restricted 2024-03-16 ff1ca63ca9a77fd44679b73aa3a20b716f6e49b61e08f2379c94f2e6c5f9a03d openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Global and local cortical folding alterations are associated with neurodevelopmental subtype in bipolar disorders : a sulcal pits analysis	Journal of affective disorders			2023	111	167

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Piguet, Camille