Molecular modeling, synthesis and biological evaluation of potential Mycobacterium tuberculosis InhA inhibitors

Diplôme Master Molecular modeling, synthesis and biological evaluation of potential Mycobacterium tuberculosis InhA inhibitors eng 2012 author Bacca Mélanie 692869 director Scapozza Leonardo 600318 director Slepikas Liudas 742594 Tuberculosis is one of the most important infectious diseases worldwide, especially in developing countries. It causes over one million deaths per year. Several treatments have been used for a long time but some resistance have emerged. Nowadays, MDR-TB, XDRTB and even TDR-TB exist. It is a emergency to find out other drugs for eradicating this threat. One of the efficient drugs is Isoniazid. This prodrug has to be activated by KatG, a mycobacterial catalase. It binds to NAD+ and this adduct inhibits the enoyl-acyl carrier protein reductase InhA, which belongs to the mycolic acid biosynthesis pathway. Research focuses on InhA direct inhibitors and rhodanine class of compound seems to have an effect on it. The aim of this project was to determine which length of the alkyl chain of several synthesized benzylrhodanine derivatives would be better for an antitubercular activity. Dewey 615 Master en pharmacie - Travail personnel de recherche 31 Section des sciences pharmaceutiques 17 false c28e15cc-4c7f-472b-9c9b-4a690fdd98f6 Master thesis Restricted BaccaMélanie_Diplomathesis2012.PDF 8037475 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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