Investigating the role of the claustrum in the communication between different cortical areas

Diplôme Thèse Investigating the role of the claustrum in the communication between different cortical areas eng 2023-05-02 2023-05-25 author Renfer Jean-Rodolphe 690897 Département de neurosciences fondamentales (NEUFO) director Carleton Alan 676577 Département de neurosciences fondamentales (NEUFO) director Rodriguez Ivan 28183 Département de génétique et évolution (Genev) (BIANI) 10.13097/archive-ouverte/unige:170169 urn:nbn:ch:unige-1701699 Neur. 372 <p>The claustrum is a small subcortical nucleus present in reptiles, birds and mammals that has extensive reciprocal connections with the whole cortex and with subcortical areas. Thus far the claustrum has been speculated to be involved in a variety of brain mechanisms, but its precise function remains unknown. We used in vivo electrophysiological recording during freely moving behavior and fear conditioning in combination with chemogenetic tools to investigate the role of the claustrum in cortico-cortical communication. We showed that inhibition of the claustrum induced a modification in the flow of information, as well as in the co-occurrence of brain oscillations associated with memory events, across distant cortical areas. These changes were associated with alterations in the consolidation and the retrieval of fear memory. Our findings indicate that the claustrum acts as a conductor of cortico-cortical communication, and that this communication is necessary for the correct expression of fear memory. </p> Diplôme commun des univ. de Genève et Lausanne. Thèse de doctorat des Universités de Genève et Lausanne Claustrum Fear memory Brain oscillations Prefrontal cortex Retrosplenial cortex Dewey 616.8 Dewey 590 44 Département de génétique et évolution 162 53 Département de neurosciences fondamentales 21A false 536 Groupe Carleton Alan (neurosciences fondamentales) 876 820 Groupe Rodriguez 1ac3e14f-e708-4de2-accb-4963dd491ae9 Thesis Restricted Thesis_RenferJR.pdf 3519510 application/pdf b002fc2a6777ac47bf96c49bc2b6363b246f6417ba9a1f776f30eaf6f1be7b4f b63fcc54-321c-4388-b8e5-54a3cf44421a Imprimatur Public Imprimatur_RenferJR.pdf 136505 application/pdf 84e1e53a03bc6b15bbff7a95030e35a0c5019bac2d077d16779049104c78283a restrictedAccess Faculté des sciences / Section de biologie / Département de génétique et évolution Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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Investigating the role of the claustrum in the communication between different cortical areas				2023	389	12

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Renfer, Jean-Rodolphe

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