Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants

Article Article scientifique Article Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants eng 2015 author Majd Hicham 689607 author Scherer Saja author Boo Stellar author Ramondetti Silvio author Cambridge Elizabeth author Raffoul Wassim author Friedrich Michael author Pittet Cuenod Brigitte Maud 114581 author Pioletti Dominique author Hinz Boris 514150 author Pietramaggiori Giorgio 667254 136-147 10.1016/j.biomaterials.2015.03.027 25907047 0142-9612 Over the past decade, various implantable devices have been developed to treat diseases that were previously difficult to manage such diabetes, chronic pain, and neurodegenerative disorders. However, translation of these novel technologies into clinical practice is often difficult because fibrotic encapsulation and/or rejection impairs device function after body implantation. Ideally, cells of the host tissue should perceive the surface of the implant being similar to the normal extracellular matrix. Here, we developed an innovative approach to provide implant surfaces with adhesive protein micropatterns. The patterns were designed to promote adhesion of fibroblasts and macrophages by simultaneously suppressing fibrogenic activation of both cell types. In a rat model, subcutaneously implanted silicone pads provided with the novel micropatterns caused 6-fold lower formation of inflammatory giant cells compared with clinical grade, uncoated, or collagen-coated silicone implants. We further show that micropatterning of implants resulted in 2-3-fold reduced numbers of pro-fibrotic myofibroblast by inhibiting their mechanical activation. Our novel approach allows controlled cell attachment to implant surfaces, representing a critical advance for enhanced biointegration of implantable medical devices. Dewey 617 57 Département de chirurgie 222 false 72 Groupe Pittet Cuenod Brigitte (chirurgie plastique et reconstructive) 96 Biomaterials 54 0cb12cdd-5027-449e-833e-5708da1a6c50 Article (Published version) Restricted 1-s2.0-S0142961215003051-main.pdf 8814230 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants	Biomaterials			2015	542	1

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Majd, Hicham