Toscana virus meningitis case in Switzerland: an example of the ezVIR bioinformatics pipeline utility for the identification of emerging viruses

Article Article scientifique Article Toscana virus meningitis case in Switzerland: an example of the ezVIR bioinformatics pipeline utility for the identification of emerging viruses eng 2015 author Cordey Samuel 507357 author Bel Michael 708985 author Petty Ii Thomas John 645271 author Docquier Mylene 513819 author Sacco Lorena 684555 author Turin Lara 649669 author Cherpillod Pascal 650028 author Emonet Stéphane 0000-0002-1201-742X 89139 Stéphane Paul Emonet author Louis Simonet Martine 42666 author Zdobnov Evgeny 636914 author Ambrosioni Czyrko Juan 668568 author Kaiser Laurent 28229 387 10.1016/j.cmi.2014.11.010 25658528 1198-743X Toscana virus (TOSV) represents a frequent cause of viral meningitis in the Mediterranean Basin that remains neglected in neighbouring countries. We report a documented TOSV meningitis case in a traveller returning from Tuscany to Switzerland. While routine serological and PCR assays could not discriminate between TOSV and Sandfly fever Naples virus infection, a high-throughput sequencing performed directly on the cerebrospinal fluid specimen and analysed with the ezVIR pipeline provided an unequivocal viral diagnostic. TOSV could be unequivocally considered as the aetiological agent, proving the potential of ezVIR to improve standard diagnostics in cases of infection with uncommon or emerging viruses. Dewey 576.5 Dewey 616 Dewey 618.97 135 Département de médecine génétique et développement 21D 56 Département de médecine 221 65 Département de réadaptation et gériatrie 22B false 400 Virologie clinique 668 493 Génomique Evolutionnaire Computationnelle 830 Clinical microbiology and infection 21 4 0dd419f8-4cad-435b-baa9-f6d6eb3ce516 Article (Published version) Public Toscana virus meningitis case in Switzerland_an example of the ezVIR bioinformatics pipeline utility for the identification of emerging viruses.pdf 469135 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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Toscana virus meningitis case in Switzerland: an example of the ezVIR bioinformatics pipeline utility for the identification of emerging viruses	Clinical microbiology and infection			2015	758	299

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