Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction

Article Article professionnel Article Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction eng 2004 author Borradori Tolsa Cristina 71921 author Zimine Slava author Warfield Simon K author Freschi Monica 67833 author Sancho P. Sousa Rossignol Ana Cristina 33169 author Lazeyras François 512748 author Hanquinet Sylviane 133458 author Pfizenmaier Mirjam 526980 author Hüppi Petra Susan 133591 132-138 10.1203/01.PDR.0000128983.54614.7E 15128927 0031-3998 Placental insufficiency with fetal intrauterine growth restriction (IUGR) is an important cause of perinatal mortality and morbidity and is subsequently associated with significant neurodevelopmental impairment in cognitive function, attention capacity, and school performance. The underlying biologic cause for this association is unclear. Twenty-eight preterm infants (gestational age 32.5 +/- 1.9 wk) were studied by early and term magnetic resonance imaging (MRI). An advanced quantitative volumetric three-dimensional MRI technique was used to measure brain tissue volumes in 14 premature infants with placental insufficiency, defined by abnormal antenatal Doppler measurements and mean birth weights <10(th) percentile (1246 +/- 299 g) (IUGR) and in 14 preterm infants matched for gestational age with normal mean birth weights 1843 +/- 246 g (control). Functional outcome was measured at term in all infants by a specialized assessment scale of preterm infant behavior. Premature infants with IUGR had a significant reduction in intracranial volume (mean +/- SD: 253.7 +/- 29.9 versus 300.5 +/- 43.5 mL, p < 0.01) and in cerebral cortical gray matter (mean +/- SD: 77.2 +/- 16.3 versus 106.8 +/- 24.6 mL, p < 0.01) when measured within the first 2 wk of life compared with control premature infants. These findings persisted at term with intracranial volume (mean +/- SD: 429.3 +/- 47.9 versus 475.9 +/- 53.4 mL, p < 0.05) and cerebral cortical gray matter (mean +/- SD: 149.3 +/- 29.2 versus 189 +/- 34.2 mL, p < 0.01). Behavioral assessment at term showed a significantly less mature score in the subsystem of attention-interaction availability in IUGR infants (p < 0.01). Cerebral cortical gray matter volume at term correlated with attention-interaction capacity measured at term (r = 0.45, p < 0.05). These results suggest that placental insufficiency with IUGR have specific structural and functional consequences on cerebral cortical brain development. These findings may provide insight into the structural-functional correlate for the developmental deficits associated with IUGR. Brain/growth & development/pathology Cerebrospinal Fluid Fetal Growth Retardation/pathology/physiopathology Head/growth & development Humans Infant Behavior Infant, Newborn Infant, Premature Magnetic Resonance Imaging Nerve Fibers/pathology Dewey 616.0757 Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 62 Département de radiologie et informatique médicale 227 false 150 L'imagerie cérébrale 184 504 Radiologie neuro-diagnostique et neuro-interventionnelle en pédiatrie 842 Pediatric research 56 1 ccf3ff2b-dcde-45c4-a322-f5ea0b1574fb Article (Published version) Restricted 132-138.pdf 246697 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction	Pediatric research	2004	595	1
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Freschi, Monica