Maternal Voice and Tactile Stimulation Modulate Oxytocin in Mothers of Hospitalized Preterm Infants: A Randomized Crossover Trial

Article Article scientifique Article Maternal Voice and Tactile Stimulation Modulate Oxytocin in Mothers of Hospitalized Preterm Infants: A Randomized Crossover Trial eng 2023-08-28 2023-08-28 author Hirschel Jessica 671836 author Carlhan-Ledermann Audrey author Ferraz Céline 675962 author Brand Laure-Anne author Filippa Manuela 0000-0002-1310-8008 890536 Services communs du CISA (EMCO) author Gentaz Edouard 0000-0003-0574-5557 123382 Section de psychologie (PSICO) author Lejeune Fleur 0000-0002-9841-1152 747374 Section de psychologie (PSICO) author Baud Olivier 0000-0001-5021-0522 850348 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) 1469 10.3390/children10091469 37761430 2227-9067 PMC10528509 https://www.mdpi.com/2227-9067/10/9/1469 <p>Prematurity is a major risk factor for perinatal stress and neonatal complications leading to systemic inflammation and abnormal mother–infant interactions. Oxytocin (OT) is a neuropeptide regulating the inflammatory response and promoting mother–infant bonding. The release of this hormone might be influenced by either vocal or tactile stimulation. The main objective of the current randomized, crossover, clinical trial was to assess the salivary OT/cortisol balance in mothers following the exposure of their baby born preterm to two types of sensorial interventions: maternal voice without or with contingent tactile stimulation provided by the mother to her infant. Among the 26 mothers enrolled, maternal voice intervention alone had no effect on OT and cortisol levels in the mothers, but when associated with tactile stimulation, it induced a significant increase in maternal saliva oxytocin (38.26 ± 30.26 pg/mL before vs 53.91 ± 48.84 pg/mL after, p = 0.02), particularly in the mothers who delivered a female neonate. Maternal voice intervention induced a significant reduction in cortisol and an increase in OT levels in mothers when the maternal voice with a tactile stimulation intervention was performed first. In conclusion, exposure to the maternal voice with a contingent tactile stimulation was associated with subtle changes in the maternal hormonal balance between OT and cortisol. These findings need to be confirmed in a larger sample size and may ultimately guide caregivers in providing the best intervention to reduce parental stress following preterm delivery.</p> Infant-directed speech Maternal voice Oxytocin Preterm infants Dewey 150 Dewey 618 108 Section de psychologie 71 58 Département de pédiatrie, gynécologie et obstétrique 223 false 641 Laboratoire du développement sensori-moteur, affectif et social (SMAS) 594 Neuroscience de l'émotion et dynamiques affectives (NEAD) 1241 Affective sciences Children 10 9 b1cdbc95-bfa3-42d5-a57a-93c5428f1455 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 2078662 application/pdf CC BY-4.0 afe02c615afd0267ebc5565abe249185738daa71c4b53fb5a8dabcc8b6660d70 openAccess Faculté de psychologie et des sciences de l'éducation / Section de psychologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Maternal Voice and Tactile Stimulation Modulate Oxytocin in Mothers of Hospitalized Preterm Infants: A Randomized Crossover Trial	Children			2023	184	97

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