Abdominal pain patterns during COVID-19: an observational study

Article Article scientifique Article Abdominal pain patterns during COVID-19: an observational study eng 2022-08-29 2022-08-29 author Balaphas Alexandre 634385 author Gkoufa Kyriaki 934071 author Colucci Nicola 951018 author Perdikis Konstantinos 675460 author Gaudet-Blavignac Christophe 0000-0001-6527-5898 645533 author Pataky Zoltan 0000-0002-8720-3833 105295 author Carballo Juan Sebastian 0000-0002-8344-4293 84409 author Ris Frédéric 53083 author Stirnemann Jérôme 793435 author Lovis Christian 0000-0002-2681-8076 29016 author Goossens Nicolas 509893 author Toso Christian 0000-0003-1652-4522 92271 14677 10.1038/s41598-022-18753-0 36038578 2045-2322 https://www.nature.com/articles/s41598-022-18753-0 Abdominal pain and liver injury have been frequently reported during coronavirus disease-2019 (COVID-19). Our aim was to investigate characteristics of abdominal pain in COVID-19 patients and their association with disease severity and liver injury. Data of all COVID-19 patients hospitalized during the first wave in one hospital were retrieved. Patients admitted exclusively for other pathologies and/or recovered from COVID-19, as well as pregnant women were excluded. Patients whose abdominal pain was related to alternative diagnosis were also excluded. Among the 1026 included patients, 200 (19.5%) exhibited spontaneous abdominal pain and 165 (16.2%) after abdomen palpation. Spontaneous pain was most frequently localized in the epigastric (42.7%) and right upper quadrant (25.5%) regions. Tenderness in the right upper region was associated with severe COVID-19 (hospital mortality and/or admission to intensive/intermediate care unit) with an adjusted odds ratio of 2.81 (95% CI 1.27-6.21, p = 0.010). Patients with history of lower abdomen pain experimented less frequently dyspnea compared to patients with history of upper abdominal pain (25.8 versus 63.0%, p < 0.001). Baseline transaminases elevation was associated with history of pain in epigastric and right upper region and AST elevation was strongly associated with severe COVID-19 with an odds ratio of 16.03 (95% CI 1.95-131.63 p = 0.010). More than one fifth of patients admitted for COVID-19 presented abdominal pain. Those with pain located in the upper abdomen were more at risk of dyspnea, demonstrated more altered transaminases, and presented a higher risk of adverse outcomes. Abdomen Abdominal Pain / etiology COVID-19 / complications Dyspnea Female Humans Pregnancy Retrospective Studies SARS-CoV-2 Transaminases Dewey 616.0757 Dewey 616 Dewey 617 57 Département de chirurgie 222 62 Département de radiologie et informatique médicale 227 56 Département de médecine 221 false 562 Transplantation et hépatologie 905 344 Interfaces Homme-machine en milieu clinique 610 1392 Pied diabétique 1043 319 Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) 585 Scientific reports 12 f3389087-07f0-4be4-944e-cccce56dfffe Article (Published version) Public s41598-022-18753-0.pdf 1100098 application/pdf CC BY-4.0 241c422c-8489-4822-9cf7-0221ec460ef5 Appendix Public 41598_2022_18753_MOESM1_ESM.docx 336961 application/vnd.openxmlformats-officedocument.wordprocessingml.document Supplementary Figure S1 7667b8f6-9cf2-4b3d-ad2c-8e1d492dc2b1 Appendix Public 41598_2022_18753_MOESM2_ESM.docx 17702 application/vnd.openxmlformats-officedocument.wordprocessingml.document Supplementary Table S1 f36edd8d-d78b-46cc-9de7-c83da34e7f24 Appendix Public 41598_2022_18753_MOESM3_ESM.docx 13786 application/vnd.openxmlformats-officedocument.wordprocessingml.document Supplementary Table S2 5d1d5eb8-e5b8-4bcd-93c8-90dd18157568 Appendix Public 41598_2022_18753_MOESM4_ESM.docx 15646 application/vnd.openxmlformats-officedocument.wordprocessingml.document Supplementary Table S3 d9b70848-9883-4462-8ade-c4b1458c0b09 Appendix Public 41598_2022_18753_MOESM5_ESM.docx 14108 application/vnd.openxmlformats-officedocument.wordprocessingml.document Supplementary Table S4 openAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Year	Views	Downloads

Dysfonction érectile : point de vue de l’angiologie	Revue médicale suisse	2025	10	0
Abdominal pain patterns during COVID-19: an observational study	Scientific reports	2022	316	162

Archive ouverte UNIGE

Perdikis, Konstantinos