Prognostic value of the echocardiographic probability of pulmonary hypertension in patients with acute decompensated heart failure

Article Article scientifique Article Prognostic value of the echocardiographic probability of pulmonary hypertension in patients with acute decompensated heart failure eng 2019-10-15 2019-10-15 author Carballo Juan Sebastian 0000-0002-8344-4293 84409 author Musso Philippe Laurent 674018 author Garin Nicolas 82767 author Mueller Hajo 0000-0001-9366-9499 89204 author Serratrice Jacques 836481 author Mach François 27365 author Carballo David Andrés 30060 author Stirnemann Jérôme 0000-0001-9964-4452 793435 1684 10.3390/jcm8101684 31618841 2077-0383 PMC6832915 The prognostic value of pulmonary hypertension (PH) estimated by echocardiography in unselected patients with acute decompensated heart failure (ADHF) is poorly studied. Between November 2014 and September 2018, 657 patients were recruited in a prospective registry of ADHF (ClinicalTrials.gov <a href="http://clinicaltrials.gov/show/NCT02444416" rel="noopener noreferrer" target="_blank">NCT02444416</a>). The probability of pulmonary hypertension was based on European Society of Cardiology (ESC) guidelines for echocardiographic evaluation. The median survival without all-cause mortality or readmission was 7 months. During the median follow-up period of 15 months, there were 450 events including 185 deaths. In multivariate analysis, the hazard ratio (HR) of all-cause mortality or readmission for patients with a high probability of PH was 1.67 (95% CI 1.29-2.17, p < 0.001) as compared to patients with a low or intermediate probability. The left ventricular ejection fraction (LVEF) and right ventricular function (RVF) were not associated with the primary outcome-HR 1.02 (95% CI 0.81-1.29; p = 0.84) and 0.96 (95% CI 0.76-1.23; p = 0.77) respectively. In patients admitted for ADHF, a high probability of PH as evaluated by echocardiography provided the highest independent prognostic value for mortality and readmission, whereas LVEF and RVF were not associated with prognosis. The identification of patients at high risk of PH by non-invasive measurement conveys important prognostic information and may guide management. Echocardiography Heart failure Pulmonary hypertension Dewey 616 56 Département de médecine 221 false 319 Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) 585 325 Athérosclérose 591 Journal of clinical medicine 8 10 1863c268-2384-47a3-9127-361293318ced Article (Published version) Public Article-scientifique-from-unpaywall.pdf 383896 application/pdf CC BY openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Year	Views	Downloads

Valeur pronostique de la probabilité échocardiographique d’hypertension pulmonaire chez des patients avec une décompensation cardiaque aigue		2022	426	445
Prognostic value of the echocardiographic probability of pulmonary hypertension in patients with acute decompensated heart failure	Journal of clinical medicine	2019	406	107

Archive ouverte UNIGE

Musso, Philippe Laurent

account_balance Affiliation entities

Affiliation entities