Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations

Article Article scientifique Revue de la littérature Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations eng 2012 author Zimmermann Anna 672631 author Preynat-Seauve Olivier 561776 author Tiercy Jean-Marie 26423 author Krause Karl-Heinz 23022 author Villard Jean 29595 2364-2373 10.1089/scd.2012.0088 22559254 1547-3287 High expectations surround the area of stem cells therapeutics. However, the cells' source-adult or embryonic-and the cells' origin-patient-derived autologous or healthy donor genetically unrelated-remain subjects of debate. Autologous origins have the advantage of a theoretical absence of immune rejection by the recipient. However, this approach has several limitations with regard to the disease of the recipient and to potential problems with the generation, expansion, and manipulation of autologous induced pluripotent stem cells (iPS cells) preparation. An alternative to using autologous cells is the establishment of a bank of well-characterized adult cells that would be used to generate iPS cells and their derivatives. In the context of transplantation, such cells would come from genetically unrelated donors and the immune system of the recipient would reject the graft without immunosuppressive therapy. To minimize the risk of rejection, human leukocyte antigen (HLA) compatibility is certainly the best option, and the establishment of an HLA-organized bank would mean having a limited number of stem cells that would be sufficient for a large number of recipients. The concept of haplobanking with HLA homozygous cell lines would also limit the number of HLA mismatches, but such an approach will not necessarily be less immunogenic in terms of selection criteria, because of the limited number of HLA-compatible loci and the level of HLA typing resolution. Cell Culture Techniques/methods Embryo, Mammalian/cytology Graft Rejection/immunology HLA Antigens/immunology Haplotypes Histocompatibility Testing/methods Homozygote Humans Induced Pluripotent Stem Cells/immunology/physiology/transplantation Parthenogenesis Stem Cell Research/ethics Tissue Banks/ethics/standards Tissue Donors Dewey 616 Dewey 616.07 Dewey 616.8 53 Département de neurosciences fondamentales 21A 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 false 299 Compatibilité tissulaire et transplantation clinique 562 298 Transplantation Immunologie et Osteoimmunologie 561 Stem cells and development 21 13 d1b60aeb-b6c6-4a6c-9c95-f8a715b56b60 Article (Published version) Public Tiercy et al StemcellesandDev.pdf 456379 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine

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Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations	Stem cells and development			2012	622	677

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Zimmermann, Anna