In vitro blood brain barrier models as a screening tool for colloidal drug delivery systems and other nanosystems

Article Article scientifique Article In vitro blood brain barrier models as a screening tool for colloidal drug delivery systems and other nanosystems eng 2010 author Garcel Aude 671535 author Martel Sophie 135666 author Carrupt Pierre-Alain 135654 author Doelker Eric 25151 author Delie Salmon Florence 121330 133-163 10.1504/IJBNN.2010.034650 1756-0799 The brain is one of the least accessible organs of the body due to the presence of the blood-brain barrier (BBB), thus making drug delivery to the brain quite a challenge. Various strategies have been explored to circumvent this physiological barrier, including the use of colloidal carriers. These carriers hold great promise as they may increase the delivery of drugs into the brain by protecting them from degradation and prolonging their circulation in the blood, as well as promoting their transport through the BBB. Moreover, functionalisation of these carriers with various ligands allows specific targeting of the central nervous system compartment. Additionally, various in vitro BBB models have been developed and are increasingly useful for screening of drug delivery systems, especially cell-based models that provide mechanistic information. In fact, this paper specifically reviews selected in vitro BBB models as a screening tool for drug delivery colloidal systems. Dewey 615 31 Section des sciences pharmaceutiques 17 false 885 Pharmacochimie International journal of biomedical nanoscience and nanotechnology 1 2/3/4 cd7dac8f-1524-437f-a9af-3cec6a8acdae Article (Published version) Public 15539.pdf 516382 application/pdf openAccess Faculté des sciences / Section des sciences pharmaceutiques

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In vitro blood brain barrier models as a screening tool for colloidal drug delivery systems and other nanosystems	International journal of biomedical nanoscience and nanotechnology			2010	1,146	1,883

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Garcel, Aude