Intravitreal formulations targeting the retinal vasculature in posterior segment eye diseases

Diplôme Thèse Intravitreal formulations targeting the retinal vasculature in posterior segment eye diseases eng 2013-02-01 author Veurink Marieke 670868 director Gurny Robert 24779 director Scapozza Leonardo 600318 director Pournaras Constantin 64719 10.13097/archive-ouverte/unige:28387 urn:nbn:ch:unige-283870 Sc. 4528 The objective of the thesis is the development of formulations for intravitreal injection that are targeting the retinal vasculature in posterior segment eye diseases. Due to the isolated structure of the eye, achieving therapeutically effective drug concentrations at the retinal tissues is challenging. The current work aims at improvement of the therapeutic efficacy of intravitreal injections. Two parts can be distinguished. The first part focuses on the prevention of angiogenesis, through the development of sustained release formulations for vasoactive compounds that are able to overcome retinal vascular occlusions. Injectable and biodegradable polymer systems, based on α-hydroxy acids, are investigated as carriers or prodrugs for this application. The second part aims at inhibiting angiogenesis, through the improvement of existing formulations that act against VEGF-A. Therapeutic antibodies are combined with corticosteroids or with small therapeutically inactive excipients. Goal of the former is a stable combo-formulation that might cause a synergistic effect, purpose of the second is to prevent aggregate formation in the antibody formulation. formulations retinal vasculature intravitreal injection biodegradable polymers antibody aggregation Dewey 615 31 Section des sciences pharmaceutiques 17 false f27f6e04-c8f2-40d6-91d8-e87acf83f9a8 Thesis Public total manuscript MV_PDF.pdf 4997855 application/pdf openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Veurink, Marieke