Involvement of the sphingosine 1-phosphate receptor 3 in neuro-inflammation

Diplôme Thèse Involvement of the sphingosine 1-phosphate receptor 3 in neuro-inflammation eng 2011-07-28 author Fischer Iris 670864 director Riezman Howard 134430 director Pouly Sandrine 10.13097/archive-ouverte/unige:17228 urn:nbn:ch:unige-172284 Sc. 4338 The S1P3 receptor belongs to the family of G protein coupled receptors which were demonstrated to have regulatory functions in all systems of the body including the immune, cardiovascular and central nervous system. In this work, the role of S1P3 was characterized in neuro-inflammation in regard to its potential role in the neurodegenerative disease multiple sclerosis. It is shown that the SphK1/S1P3 axis is important in astrocyte signalling and probably involved in their activation in vitro. The work further shows that S1P3 is expressed on reactive astrocyte in MS lesions, but not in the mouse brain during neuro-inflammation. In an EAE study, an animal model used to investigate aspects of the human disease multiple sclerosis, it is demonstrated that S1P3 plays no major role in EAE. The therapeutic relevance of these findings remains open, as S1P3 seems to be able to mediate both deleterious and beneficial effects on astrocytes in MS. Multiple sclerosis S1P3 Neuro-inflammation Dewey 540 39 Département de biochimie 144 false feae68a7-ea4c-41af-a797-7c64add7447d Thesis Public Thesis 03Oct_2011_IF.pdf 7111689 application/pdf openAccess Faculté des sciences / Section de chimie et biochimie / Département de biochimie

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Fischer, Iris