Clinical, behavioural and neural validation of the PANSS amotivation factor

Article Article scientifique Article Clinical, behavioural and neural validation of the PANSS amotivation factor eng 2020 author Kaliuzhna Mariia 904560 author Kirschner Matthias author Carruzzo Fabien 0000-0003-2386-3389 834756 author Hartmann-Riemer Matthias N author Bischof Martin 670174 author Seifritz Erich author Tobler Philippe N author Kaiser Stefan 0000-0002-3013-2034 868946 38-45 10.1016/j.schres.2020.04.018 32349887 0920-9964 Negative symptoms in schizophrenia have been suggested to map onto two distinct factors - amotivation and diminished expression. Only recently, two-factor solutions for measuring negative symptoms have been proposed for the Positive and Negative Symptom Scale (PANSS), the most commonly used scale to assess the psychopathology of patients with schizophrenia. We aimed to validate the PANSS two-factor structure on a clinical, behavioural and neural level. For this multi-level validation, we reanalysed several datasets with patients for whom both the Brief Negative Symptom Assessment Scale (BNSS) and PANSS data were collected. We used a clinical dataset (n = 120) as well as behavioural data from an effort-based decision making task (n = 31) and functional neuroimaging data from a monetary incentive delay task (n = 41). Both tasks have previously been shown to be associated with BNSS amotivation. On the clinical level, the PANSS amotivation and diminished expression were highly correlated with their BNSS counterparts. On the behavioural level, we found that the PANSS amotivation factor but not the diminished expression factor specifically associated with willingness to invest effort to obtain a reward. On the neural level, PANSS amotivation was specifically related to reduced ventral striatal activation during reward anticipation. Our data confirm that the PANSS clearly allows distinguishing amotivation from diminished expression, as it relates selectively to specific aspects of behaviour and brain function. Our results will allow a re-analysis and sharing of existing datasets that used the PANSS to further substantiate the distinction between the two factors in neuroscientific studies and clinical trials. Amotivation BNSS Diminished expression Negative symptoms PANSS Schizophrenia Dewey 616.89 60 Département de psychiatrie 225 false 1236 Psychopathologie clinique et expérimentale 987 Schizophrenia Research 220 066c6e0d-37b6-4405-9d1d-7e6f119ed575 Article (Published version) Restricted 1-s2.0-S0920996420302255-main.pdf 753294 application/pdf a45977b1-8b23-4416-9073-d3503e2d1c59 Supplemental data Restricted 1-s2.0-S0920996420302255-mmc1.docx 36246 application/vnd.openxmlformats-officedocument.wordprocessingml.document restrictedAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Clinical, behavioural and neural validation of the PANSS amotivation factor	Schizophrenia Research			2020	298	0

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Bischof, Martin