Regulation of telomere addition at DNA double-strand breaks

Article Article scientifique Article Regulation of telomere addition at DNA double-strand breaks eng 2013 author Ribeyre Cyril 665614 author Shore David M. 102587 159-173 10.1007/s00412-013-0404-2 0009-5915 Telomeres constitute the ends of linear eukaryotic chromosomes. Due to the conventional mode of DNA replication, telomeric DNA erodes at each cell division. To counteract this, a specialized reverse transcriptase, telomerase, can elongate chromosome ends to maintain them at a constant average length. Because of their similarity to DNA double-strand breaks (DSBs), telomeres might be expected to induce a DNA damage response, which would lead to repair reactions and the generation of translocations or fusions. Many proteins present at telomeres prevent this by protecting (capping) the chromosome termini. Conversely, a DSB occurring in other regions of the genome, due, for instance, to a stalled replication fork or genotoxic agents, must be repaired by homologous recombination or end-joining to ensure genome stability. Interestingly, telomerase is able to generate a telomere de novo at an accidental DSB, with potentially lethal consequences in haploid cells and, at a minimum, loss of heterozygosity (LOH) in diploid cells. Recent data suggest that telomerase is systematically recruited to DSBs but is prevented from acting in the absence of a minimal stretch of flanking telomere-repeat sequences. In this review, we will focus on the mechanisms that regulate telomere addition to DSBs. Dewey 570 Dewey 590 Open Access - Licence nationale Springer 23 Institut de génétique et de génomique 0DH 43 Département de biologie moléculaire 161 false Chromosoma 122 3 24591595-2405-4750-8cc3-482a96dd23fa Article (Published version) Public Ribeyre-Shore2013_Article_RegulationOfTelomereAdditionAt.pdf 410746 application/pdf openAccess Centres et instituts / Institut de génétique et de génomique Faculté des sciences / Section de biologie / Département de biologie moléculaire

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Regulation of telomere addition at DNA double-strand breaks	Chromosoma			2013	440	505

Archive ouverte UNIGE

Ribeyre, Cyril