Prone versus supine free-breathing for right-sided whole breast radiotherapy

Article Article scientifique Article Prone versus supine free-breathing for right-sided whole breast radiotherapy eng 2022-01-11 author Fargier-Bochaton Odile Brigitte Pascale Radiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland. 543863 Odile Fargier-Bochaton author Wang Xinzhuo Radiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.,Radiation Oncology, Tianjin Union Medical Center, Tianjin, 300121, China. 804534 author Dipasquale Giovanna 0000-0002-9225-9559 Radiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland. 863384 author Laouiti Mohamed Radiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.,Service de Radio-Oncologie, Hôpital Riviera-Chablais, Rennaz, Switzerland. 663877 author Kountouri Melpomeni Radiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland. 912076 author Gorobets Olena CHU de Martinique, Fort-de-France, Martinique, France. author Nguyen Nam P Radiation Oncology, Howard University, Washington, DC, USA. author Miralbell Raymond Radiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland. raymond.miralbell@unige.ch.,Université de Genève, Geneva, Switzerland. raymond.miralbell@unige.ch.,Centro de Protonterapia Quirónsalud, Pozuelo de Alarcón, 28223, Madrid, Spain. raymond.miralbell@unige.ch.,Servei de Radiooncologia, Institut Oncològic Teknon, Quironsalud, Vilana 12, 08022, Barcelona, Spain. raymond.miralbell@unige.ch. 116361 author Vinh Hung Vincent 0000-0002-6403-6120 Radiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.,CHU de Martinique, Fort-de-France, Martinique, France. 660954 525 10.1038/s41598-021-04385-3 35017568 2045-2322 PMC8752750 https://www.nature.com/articles/s41598-021-04385-3 Prone setup has been advocated to improve organ sparing in whole breast radiotherapy without impairing breast coverage. We evaluate the dosimetric advantage of prone setup for the right breast and look for predictors of the gain. Right breast cancer patients treated in 2010-2013 who had a dual supine and prone planning were retrospectively identified. A penalty score was computed from the mean absolute dose deviation to heart, lungs, breasts, and tumor bed for each patient's supine and prone plan. Dosimetric advantage of prone was assessed by the reduction of penalty score from supine to prone. The effect of patients' characteristics on the reduction of penalty was analyzed using robust linear regression. A total of 146 patients with right breast dual plans were identified. Prone compared to supine reduced the penalty score in 119 patients (81.5%). Lung doses were reduced by 70.8%, from 4.8 Gy supine to 1.4 Gy prone. Among patient's characteristics, the only significant predictors were the breast volumes, but no cutoff could identify when prone would be less advantageous than supine. Prone was associated with a dosimetric advantage in most patients. It sets a benchmark of achievable lung dose reduction.Trial registration: ClinicalTrials.gov NCT02237469, HUGProne, September 11, 2014, retrospectively registered. Adult Aged Breast / radiation effects Breast Neoplasms / radiotherapy Female Humans Lung / radiation effects Middle Aged Organs at Risk / radiation effects Patient Positioning / methods Prone Position Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted / methods Respiration Retrospective Studies Supine Position Dewey 616.0757 62 Département de radiologie et informatique médicale 227 false https://data.mendeley.com/datasets/rv7pjnfhxx/1 Scientific reports 12 1 3c731427-8fef-4b8e-98b6-d76659020216 Article (Published version) Public Article_scientifique_from_crossref.pdf 3039372 application/pdf CC BY-4.0 e7592cfc721c9956348bc5d6d63d1431e9289e2b4436bd1ad1d447b4b4d7adab openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Prone versus supine free-breathing for right-sided whole breast radiotherapy	Scientific reports	2022	3	4
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Laouiti, Mohamed