Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation

Article Article scientifique Article Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation eng 2021-10-21 2021-10-21 author Kebets Valeria 0000-0003-1707-7437 646772 author Favre Pauline 0000-0002-8137-0358 657539 author Houenou Josselin author Polosan Mircea author Perroud Nader Ali 0000-0002-9282-9216 94458 author Aubry Jean-Michel 32998 author Van De Ville Dimitri 0000-0002-2879-3861 638484 author Piguet Camille Marie 0000-0003-4317-0918 541240 Camille Marie Nemitz 545 10.1038/s41398-021-01666-3 34675186 2158-3188 PMC8530999 https://www.nature.com/articles/s41398-021-01666-3 Emotion dysregulation is central to the development and maintenance of psychopathology, and is common across many psychiatric disorders. Neurobiological models of emotion dysregulation involve the fronto-limbic brain network, including in particular the amygdala and prefrontal cortex (PFC). Neural variability has recently been suggested as an index of cognitive flexibility. We hypothesized that within-subject neural variability in the fronto-limbic network would be related to inter-individual variation in emotion dysregulation in the context of low affective control. In a multi-site cohort (N = 166, 93 females) of healthy individuals and individuals with emotional dysregulation (attention deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), and borderline personality disorder (BPD)), we applied partial least squares (PLS), a multivariate data-driven technique, to derive latent components yielding maximal covariance between blood-oxygen level-dependent (BOLD) signal variability at rest and emotion dysregulation, as expressed by affective lability, depression and mania scores. PLS revealed one significant latent component (r = 0.62, p = 0.044), whereby greater emotion dysregulation was associated with increased neural variability in the amygdala, hippocampus, ventromedial, dorsomedial and dorsolateral PFC, insula and motor cortex, and decreased neural variability in occipital regions. This spatial pattern bears a striking resemblance to the fronto-limbic network, which is thought to subserve emotion regulation, and is impaired in individuals with ADHD, BD, and BPD. Our work supports emotion dysregulation as a transdiagnostic dimension with neurobiological underpinnings that transcend diagnostic boundaries, and adds evidence to neural variability being a relevant proxy of neural efficiency. Amygdala / diagnostic imaging Borderline Personality Disorder Emotions Female Hippocampus Humans Magnetic Resonance Imaging Neuroscience Psychiatric disorders Biomarkers Dewey 616.0757 Dewey 616.89 French National Research Agency (ANR) Labex BioPsy ANR-11-IDEX-004-02 French National Research Agency (ANR) ANR-10-COHO-10-01 Swiss National Science Foundation NCCR SYNAPSY: The synaptic bases of mental diseases (phase II) CH Programmes Swiss National Science Foundation Investigating functional neural circuit vulnerability and biomarkers in high-risk offspring and normothymic bipolar disorder patients 32003B_156914 CH Project funding French National Research Agency (ANR) France Life Imaging ANR-11-INBS-0006 FLI FR 60 Département de psychiatrie 225 62 Département de radiologie et informatique médicale 227 false 1342 Régulation des émotions : TDAH et trouble de la personnalité borderline 1028 417 Thérapeutiques des Troubles de l'Humeur et Anxieux 689 552 Traitement d'images médicales 893 Translational psychiatry 11 1 1c6345ac-2a6a-4264-9f3f-9f890417e6b4 Article (Published version) Public Article-scientifique-from-europePmc.pdf 923582 application/pdf CC BY-4.0 f26d2fcb-b120-4697-b87a-8baf1e7b7aa0 Appendix Public 41398_2021_1666_MOESM1_ESM.docx 1318449 application/vnd.openxmlformats-officedocument.wordprocessingml.document openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation	Translational psychiatry			2021	318	255

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Favre, Pauline