Association between SARS-CoV-2 infection and anti-apolipoprotein A-1 antibody in children

Article Article scientifique Article Association between SARS-CoV-2 infection and anti-apolipoprotein A-1 antibody in children eng 2025-02-26 author Vuilleumier Nicolas Division of Laboratory Medicine, Diagnostics Department, Geneva University Hospitals, Geneva, Switzerland.,Department of Medicine, Medical Faculty, Geneva University, Geneva, Switzerland. 61406 Département de médecine (DEMED) author Pagano Sabrina 0000-0001-7075-1182 Division of Laboratory Medicine, Diagnostics Department, Geneva University Hospitals, Geneva, Switzerland.,Department of Medicine, Medical Faculty, Geneva University, Geneva, Switzerland. 758239 author Lorthe Elsa Louise Adèle Unit of Population Epidemiology, Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.,Université Paris Cité, Inserm, National Research Institute for Agriculture, Food and the Environment, Centre for Research in Epidemiology and Statistics Paris, Paris, France.,Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland. 416911 author Lamour Julien Unit of Population Epidemiology, Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Nehme Mayssam Unit of Population Epidemiology, Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. 840942 Département de santé et médecine communautaire (MECOM) author Juillard Mochon Catherine Division of Laboratory Medicine, Diagnostics Department, Geneva University Hospitals, Geneva, Switzerland. 26802 author Barbe Remy Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, Geneva, Switzerland.,Division of Child and Adolescent Psychiatry, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland. 527289 author Posfay Barbe Klara Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, Geneva, Switzerland.,Division of General Pediatrics, Department of Women, Child and Adolescent Medicine, University Hospitals of Geneva, Geneva, Switzerland. 39230 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Guessous Idris Unit of Population Epidemiology, Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.,Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 760565 Médecine de premier recours hospitalo-universitaire (MPRHU) author Stringhini Silvia Unit of Population Epidemiology, Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.,Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,School of Population and Public Health and Edwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. 830749 Médecine de premier recours hospitalo-universitaire (MPRHU) author L'Huillier Arnaud 0000-0001-9230-7285 Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, Geneva, Switzerland.,Pediatric Infectious Diseases Unit, Department of Women, Child and Adolescent Health, Geneva University Hospitals, Geneva, Switzerland. 543058 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) SEROCoV-KIDS study group collaborator Azman Andrew 0000-0001-8662-9077 954616 collaborator Bal Antoine collaborator Baysson Hélène 0000-0003-4676-4500 927962 Hélène BAYSSON collaborator Bouchet Aminata collaborator D’Ippolito Paola collaborator Dumont Roxanne collaborator El Merjani Nacira collaborator Pennacchio Francesco collaborator Francioli Natalie collaborator Harnal Severine 417938 collaborator Loizeau Andréa 677311 collaborator Martinez Chantal 591418 collaborator Mechoullam Shannon 818134 collaborator Poulain Géraldine 868190 collaborator Pugin Caroline 926418 collaborator Pullen Nick collaborator Richard Viviane Adissa 899625 collaborator Rochat Michèle Deborah 83757 collaborator Rouzinov Serguei 657192 collaborator Samir Khadija 417937 collaborator Schrempft Stéphanie 931965 collaborator Testini Stéphanie 808001 collaborator Urrutia Rivas Deborah 840320 collaborator Uppal Anshu 689182 collaborator Verolet Charlotte 646895 collaborator Villers Jennifer Annick M. 941947 Département de pathologie et immunologie (PATIM) collaborator Violot Guillemette collaborator Zaballa María-Eugenia 1521299 10.3389/fimmu.2025.1521299 40079006 1664-3224 PMC11897246 https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521299/full Background and aims: Autoantibodies against apolipoprotein A-1 (AAA1) are elicited by SARS-CoV-2 infection and predict COVID-19 symptoms persistence at one year in adults, but whether this applies to children is unknown. We studied the association of SARS-CoV-2 exposure with AAA1 prevalence in children and the association of AAA1 seropositivity with symptom persistence. Methods: Anti-SARS-CoV-2 and AAA1 serologies were examined in 1031 participants aged 6 months to 17 years old from the prospective SEROCOV-KIDS cohort and recruited between 12.2021 and 02.2022. Four SARS-CoV-2 serology-based groups were defined: "Infected-unvaccinated (I+/V-)", "Uninfected-vaccinated (I-/V+)", "Infected-Vaccinated (I+/V+)", and "Naïve (I-/V-)". Reported outcomes were collected using online questionnaires. Associations with study endpoints were assessed using logistic regression. Results: Overall, seropositivity rates for anti-RBD, anti-N, and AAA1 were 71% (736/1031), 55% (568/1031), and 5.8% (60/1031), respectively. AAA1 showed an inverse association with age but not with any other characteristics. The I+/V- group displayed higher median AAA1 levels and seropositivity (7.9%) compared to the other groups (p ≤ 0.011), translating into a 2-fold increased AAA1 seroconversion risk (Odds ratio [OR]: 2.11, [95% Confidence Interval (CI)]: 1.22-3.65; p=0.008), unchanged after adjustment for age and sex. AAA1 seropositivity was independently associated with a 2-fold odds of symptoms persistence at ≥ 4 weeks (p ≤ 0.03) in the entire dataset and infected individuals, but not ≥ 12 weeks. Conclusions: Despite the limitations of the study (cross-sectional design, patient-related outcomes using validated questionnaires), the results indicate that SARS-CoV-2 infection could elicit an AAA1 response in children, which could be independently associated with short-time symptoms persistence. SARS-CoV-2 Apolipoprotein A-1 Autoantibodies Pediatrics Symptom persistence Dewey 613 Dewey 616 Dewey 618 56 Département de médecine 221 64 Département de santé et médecine communautaires 22A 58 Département de pédiatrie, gynécologie et obstétrique 223 false 211 Auto-immunité, inflammation et athérosclérose 270 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 1313 Médecine de 1er recours 1020 Frontiers in immunology 16 d465fbc2-ece7-4b1c-8d7b-761ce0bf8ddd Article (Published version) Public fimmu-16-1521299.pdf 400086 application/pdf CC BY-4.0 6526fe3a1782a7ab09ac7ba8b023690fb110e505abc3e002fb6e7198a8808aab openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Association between SARS-CoV-2 infection and anti-apolipoprotein A-1 antibody in children	Frontiers in immunology			2025	62	126

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