Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

Article Article scientifique Article Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults eng 2017 author Hasler Roland 510492 author Preti Maria Giulia 808407 author Meskaldji Djalel Eddine 812758 author Prados Julien 0000-0002-8546-241X 561771 author Adouan Wafae 661103 author Rodriguez C. author Toma S. author Hiller Nikol 675552 author Ismaili Tringa 655172 author Hofmeister Jérémy 0000-0002-0071-8499 643702 author Sinanaj Indrit 0000-0001-5350-4454 715639 Indrit Bègue author Baud P. author Haller Sven 711086 author Giannakopoulos Panteleimon 44657 author Schwartz Sophie 0000-0001-7718-4053 35633 author Perroud Nader Ali 0000-0002-9282-9216 94458 author Van De Ville Dimitri 0000-0002-2879-3861 638484 10.1016/j.pscychresns.2017.09.004 28938222 0925-4927 http://linkinghub.elsevier.com/retrieve/pii/S0925492716303018 Attention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults. Resting-state fMRI was acquired from 30 ADHD and 15 healthy adults. For each subject, rs7210438 and rs8079626 within the gene BAIAP2 were genotyped. ADHD severity, impulsiveness and anger were assessed for the ADHD group. Using multivariate analysis of variance, we found that genetic features do have an impact on DMN FC asymmetry. In particular, polymorphism rs8079626 affects medial frontal gyrus and inferior parietal lobule connectivity asymmetry, lower for AA than AG/GG carriers. Further, when combining FC asymmetry and the presence of the rs8079626 variant, we successfully predicted increased externalization of anger in ADHD. In conclusion, a complex interplay between genetic vulnerability and inter-hemispherical DMN FC asymmetry plays a role in emotion regulation in adult ADHD. Attention deficit hyperactivity disorder Magnetic Resonance Imaging fMRI Resting-state Default Mode Network Behavioral measures Gene polymorphism Dewey 616 Dewey 616.0757 Dewey 616.8 Dewey 616.89 53 Département de neurosciences fondamentales 21A 54 Département de microbiologie et médecine moléculaire 21B 60 Département de psychiatrie 225 62 Département de radiologie et informatique médicale 227 false 161 Groupe Giannakopoulos Panteleimon (psychiatrie générale) 201 926 Imagerie per-opératoire multi-modalité en radiologie interventionnelle 949 495 Neuroimagerie du Sommeil et de la Cognition 832 417 Thérapeutiques des Troubles de l'Humeur et Anxieux 689 552 Traitement d'images médicales 893 Psychiatry Research: Neuroimaging 269 54-61 1a1c009f-abb9-4de2-955c-48671f022d09 Article (Published version) Public Hasler_PsyRes2017.pdf 405215 application/pdf CC BY-NC-ND openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Title	Published in	Year	Views	Downloads

Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults	Psychiatry Research: Neuroimaging	2017	749	326
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