Early postnatal migration and development of layer II pyramidal neurons in the rodent cingulate/retrosplenial cortex

Article Article scientifique Article Early postnatal migration and development of layer II pyramidal neurons in the rodent cingulate/retrosplenial cortex eng 2012 author Zgraggen Eloisa 528405 author Boitard Michael 668765 author Roman Inge 651426 author Kanemitsu Michiko 585110 author Potter Gael 508624 author Salmon Patrick 505385 author Vutskits Laszlo 0000-0001-8752-9588 109383 author Dayer Alexandre 84495 author Kiss Jozsef Zoltan 22758 144-157 10.1093/cercor/bhr097 21625013 1047-3211 The cingulate and retrosplenial regions are major components of the dorsomedial (dm) limbic cortex and have been implicated in a range of cognitive functions such as emotion, attention, and spatial memory. While the structure and connectivity of these cortices are well characterized, little is known about their development. Notably, the timing and mode of migration that govern the appropriate positioning of late-born neurons remain unknown. Here, we analyzed migratory events during the early postnatal period from ventricular/subventricular zone (VZ/SVZ) to the cerebral cortex by transducing neuronal precursors in the VZ/SVZ of newborn rats/mice with Tomato/green fluorescent protein-encoding lentivectors. We have identified a pool of postmitotic pyramidal precursors in the dm part of the neonatal VZ/SVZ that migrate into the medial limbic cortex during the first postnatal week. Time-lapse imaging demonstrates that these cells migrate on radial glial fibers by locomotion and display morphological and behavioral changes as they travel through the white matter and enter into the cortical gray matter. In the granular retrosplenial cortex, these cells give rise to a Satb2+ pyramidal subtype and develop dendritic bundles in layer I. Our observations provide the first insight into the patterns and dynamics of cell migration into the medial limbic cortex. Age Factors Animals Animals, Newborn Bromodeoxyuridine/metabolism Cell Movement/genetics Cerebral Ventricles/cytology/growth & development Dendrites/metabolism Gene Expression Regulation, Developmental/genetics Genetic Vectors/physiology Glutamate Decarboxylase/genetics Green Fluorescent Proteins/genetics Gyrus Cinguli/cytology/growth & development Lentivirus/genetics Luminescent Proteins/genetics Matrix Attachment Region Binding Proteins/metabolism Mice Mice, Transgenic Microscopy, Confocal Nerve Tissue Proteins/metabolism Neural Stem Cells/physiology Pyramidal Cells/physiology/ultrastructure T-Box Domain Proteins/metabolism Transcription Factors/metabolism Ubiquitin/genetics Dewey 616.8 Dewey 617 53 Département de neurosciences fondamentales 21A 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 543 Anesthésie et neurosciences 883 535 Groupe Dayer Alexandre (Formation du circuit cortical) 875 112 Progéniteurs neuronaux 141 Cerebral cortex 22 1 9223e001-0fa6-47c4-a8f7-f72faaf1a0f7 Article (Published version) Restricted PMID21625013.pdf 2410886 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Early postnatal migration and development of layer II pyramidal neurons in the rodent cingulate/retrosplenial cortex	Cerebral cortex			2012	641	5

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