Towards a parsimonious analysis of regeneration and self-repair in animal evolution

Conférence Chapitre d'actes Towards a parsimonious analysis of regeneration and self-repair in animal evolution eng 2007 author Benenati Gaspare 649700 author Montoya Burgos Juan Ignacio 47049 author Galliot Brigitte 0000-0001-7596-8284 29979 410 978-80-87139-68-4 http://books.google.ch/books/about/IPCAT.html?id=n4K8tgAACAAJ&redir_esc=y All metazoan phyla contain species that undergo regeneration after amputation. Simple organisms as Hydra or planarians regenerate their main body axes, while salamanders and fish regenerate complex structures such as limbs, fins, tails but also heart, retina, lens. Hence, in these species the developmental programs remain accessible to reactivation throughout life, whereas in frogs they become locked after metamorphosis and in most mammals, adult regeneration is restricted to tissues as bone, liver. The consensus view is that regeneration is an ancestral character, randomly maintained or lost along evolution. To identify the possible homologies among the various regenerative processes, we selected 30 regenerative contexts where the cellular processes driving blastema formation as dedifferentiation, transdifferentiation, stem cell recruitment or proliferation of differentiated cells, were characterized. Moreover the complexity of the regenerative process and three developmental criteria including the developmental status when regeneration occurs, the presence of metamorphosis or asexual reproduction in adulthood were considered. These features were assembled to form a "regenerative code" that defines each regenerative context. These regenerative codes were then analysed under the maximum parsimony criteria to define groups of processes sharing common features. A majority-rule consensus tree shows seven unambiguous groupings that support the validity of this approach. Animal regeneration Evolution Self-repairing model systems Maximum parsimony analysis Dewey 590 Oxford Oxford University Swiss National Science Foundation 3100A0-103916 CH 44 Département de génétique et évolution 162 false 821 Groupe Galliot Proceedings of the Seventh International Workshop on Information Processing in Cells and Tissues (IPCAT 2007) Nigel Crook & Tjeerd olde Scheper 29-31 August 2007 Jesus College Oxford University 46f16467-c957-47a0-b9df-be2672cafc02 Proceedings chapter (Accepted version) Public Galliot-IPCAT2007-30-final v2.pdf 1607036 application/pdf openAccess Faculté des sciences / Section de biologie / Département de génétique et évolution

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Towards a parsimonious analysis of regeneration and self-repair in animal evolution	Proceedings of the Seventh International Workshop on Information Processing in Cells and Tissues (IPCAT 2007)			2007	721	125

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Benenati, Gaspare