HLA and non-HLA polymorphisms in renal transplantation

Article Article scientifique Revue de la littérature HLA and non-HLA polymorphisms in renal transplantation eng 2012 author Laperrousaz Stéphanie Lidia 645095 author Tiercy Jean-Marie 26423 author Villard Jean 29595 author Ferrari-Lacraz Sylvie 36049 w13668 10.4414/smw.2012.13668 22936316 0036-7672 Despite progress made in the field of immunosuppression, graft rejection remains a major cause of morbidity and mortality of patients after solid organ transplantation. There are several genetic causes which could influence the outcome of renal transplantation. One of the main determining factors of success in renal transplantation is human leukocyte antigen (HLA) compatibility between donor and recipient, particularly at HLA-A, HLA-B and HLA-DR loci. HLA compatibility remains an essential immunological barrier, despite modern immunosuppressive treatments. There is also evidence that natural killer (NK) cell alloreactivity contributes to the immune response which modulates the outcome of renal transplantation. However, the clinical impact of combinations of KIR genes (family of NK cell receptors) and their HLA ligands in donor and recipient still remains to be clearly established. Furthermore, cytokines are involved in the immune reaction against the renal transplant, but the implication of the genetic polymorphism of cytokines is strongly debated. Therefore, while HLA compatibility remains a primordial component for any renal transplantation, it would be premature to use the two other genetic aspects as criteria for organ allocation and as prognostic factors. Cytokines/genetics/immunology Genetic Markers Graft Rejection/genetics/immunology/prevention & control HLA Antigens/genetics/immunology Humans Kidney Transplantation/immunology Killer Cells, Natural/immunology Polymorphism, Genetic Receptors, KIR/genetics/immunology Dewey 616 56 Département de médecine 221 false 298 Immunologie de transplantation, immunogénétique et thérapie cellulaire 561 Schweizerische medizinische Wochenschrift 142 eab2dafe-b49e-43f2-ae46-fd1a2896c827 Article (Published version) Restricted Laperrousaz S - SMW - 2012.pdf 814022 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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HLA and non-HLA polymorphisms in renal transplantation	Schweizerische medizinische Wochenschrift			2012	613	1

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Laperrousaz, Stéphanie Lidia