Specific activation of the paralemniscal pathway during nociception

Article Article scientifique Article Specific activation of the paralemniscal pathway during nociception eng 2014-03-02 2014-05 author Frangeul Laura 0000-0002-2997-0989 Department of Basic Neurosciences, University of Geneva, 1 rue Michel Servet, 1211, Geneva, Switzerland. 705600 Département de neurosciences fondamentales (NEUFO) author Porrero Cesar author Garcia-Amado Maria author Maimone Benedetta Pilar 644157 author Maniglier Madlyne 726339 author Clascá Francisco author Jabaudon Denis 0000-0003-2438-4769 682473 Département de neurosciences fondamentales (NEUFO) 1455-1464 10.1111/ejn.12524 24580836 0953-816X https://onlinelibrary.wiley.com/doi/10.1111/ejn.12524 Two main neuronal pathways connect facial whiskers to the somatosensory cortex in rodents: (i) the lemniscal pathway, which originates in the brainstem principal trigeminal nucleus and is relayed in the ventroposterior thalamic nucleus and (ii) the paralemniscal pathway, originating in the spinal trigeminal nucleus and relayed in the posterior thalamic nucleus. While lemniscal neurons are readily activated by whisker contacts, the contribution of paralemniscal neurons to perception is less clear. Here, we functionally investigated these pathways by manipulating input from the whisker pad in freely moving mice. We report that while lemniscal neurons readily respond to neonatal infraorbital nerve sectioning or whisker contacts in vivo, paralemniscal neurons do not detectably respond to these environmental changes. However, the paralemniscal pathway is specifically activated upon noxious stimulation of the whisker pad. These findings reveal a nociceptive function for paralemniscal neurons in vivo that may critically inform context-specific behaviour during environmental exploration. Mouse Sensory physiology Somatosensory cortex Thalamocortical pathways Animals Mice Mice, Inbred C57BL Nociception / physiology Proto-Oncogene Proteins c-fos / metabolism Trigeminal Nucleus, Spinal / metabolism Trigeminal Nucleus, Spinal / physiology Vibrissae / innervation Dewey 616.8 Swiss National Science Foundation Molecular Identity and Development of Layer 4 Thalamorecipient Neurons of the Neocortex 146337 CH Careers 53 Département de neurosciences fondamentales 21A 61 Département des neurosciences cliniques 226 false 540 Neurobiologie développementale et plasticité 880 European journal of neuroscience 39 9 08ae046a-1b1c-4ab9-973e-153a241b1c84 Article (Published version) Restricted Eur_J_of_Neuroscience_-_2014_-_Fran.pdf 2774918 application/pdf 14ee8f3eecce383e3349245298d76dd03e38d113efe3157707c27e054794d969 693a8268-a354-4f1a-8513-c30f60a73d57 Supplemental data Restricted ejn12524-sup-0001-figs1-s2.pdf 2653710 application/pdf a310893227080f0ee0053d07f1a4455bf9e09910a9efa3616da0e62ae0658c2b restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Title	Published in	Year	Views	Downloads

Specific activation of the paralemniscal pathway during nociception	European journal of neuroscience	2014	23	0
Activity-Dependent Controls Over POm Thalamocortical Connectivity During Development		2011	335	10

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Maimone, Benedetta Pilar