Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma

Article Article scientifique Article Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma eng 2016 author D'Amato Dos Reis Brito Cintia 768093 author Cipriano Davide 642435 author Colin Didier 797893 author Germain Stéphane 664434 author Seimbille Yann 640596 author Roberts John Haig 67490 author Triponez Frédéric 28673 author Serre Beinier Véronique 0000-0002-6016-1645 123229 11512-11525 10.18632/oncotarget.7314 26883190 1949-2553 http://www.oncotarget.com/abstract/7314 Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine implicated in acute and chronic inflammatory diseases. MIF is overexpressed in various tumors. It displays a number of functions that provide a direct link between the process of inflammation and tumor growth. Our group recently identified the MIF-receptor CD74 as an independent prognostic factor for overall survival in patients with malignant pleural mesothelioma. In the present study, we compared the levels of expression of MIF and CD74 in different human mesothelioma cell lines and investigated their physiopathological functions in vitro and in vivo. Human mesothelioma cells expressed more CD74 and secreted less MIF than non tumoral MeT5A cells, suggesting a higher sensitivity to MIF. In mesothelioma cells, high MIF levels were associated with a high multiplication rate of cells. In vitro, reduction of MIF or CD74 levels in both mesothelioma cell lines showed that the MIF/CD74 signaling pathway promoted tumor cell proliferation and protected MPM cells from apoptosis. Finally, mesothelioma cell lines expressing high CD74 levels had a low tumorigenic potential after xenogeneic implantation in athymic nude mice. Cancer Pleura Mesothelioma Macrophage migration inhibitory factor (MIF) CD74 Dewey 617 57 Département de chirurgie 222 false 902 Cancer du poumon et mésothéliome pleural malin 944 Oncotarget 7 10 ff6146eb-b975-4791-a46c-209287600473 Article (Published version) Public Oncotarget_Feb11,2016.pdf 3781781 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma	Oncotarget			2016	583	189

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Cipriano, Davide