Maturation induced transcriptional silencing in human and mouse Dendritic Cells

Diplôme Master Maturation induced transcriptional silencing in human and mouse Dendritic Cells eng 2015 author Horiguchi Daichi 641431 director Reith Walter 25482 director Martinou Jean-Claude 27293 The primary objective of this study is to document the transcriptional silencing of ALOX15, LTA4H, PIK3CA, PIK3CG, MAP2K6, PTGS1 and SYK genes in mature DCs. Specific aims were as follows. 1) Characterize the reduction in expression of these genes over time in DCs exposed to different maturation inducing stimuli, at the mRNA and protein levels. 2) Study the potential conservation of their transcriptional repression in several subtypes of mouse DCs. 3) Gain insight into the mechanism responsible for transcriptional silencing by evaluating epigenetic regulation and transcription factor binding to the promoter regions of these genes. Dewey 570 Master en Biologie 46 Département de biologie cellulaire 165 false 221 Groupe Reith Walter (pathologie et immunologie) 282 39ca1b0f-763c-4a86-8b21-4b952f7ffe26 Master thesis Restricted Master (final version).pdf 1543492 application/pdf restrictedAccess Faculté des sciences / Section de biologie / Département de biologie cellulaire

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Maturation induced transcriptional silencing in human and mouse Dendritic Cells				2015	199	8

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Horiguchi, Daichi