The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

Article Article scientifique Article The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003 eng 2003 author Boeckmann Brigitte 639266 author Bairoch Amos Marc 0000-0003-2826-6444 21964 author Apweiler Rolf author Blatter Marie-Claude 22955 author Estreicher Von Rozbierski Anne Isabelle 23310 author Gasteiger Elisabeth 101626 author Martin Maria J author Michoud Karine Florence 88908 author O'Donovan Claire author Phan Isabelle 639323 author Pilbout Sandrine 639325 author Schneider Michel 639335 365-370 10.1093/nar/gkg095 12520024 0305-1048 http://nar.oxfordjournals.org/content/31/1/365.long The SWISS-PROT protein knowledgebase (http://www.expasy.org/sprot/ and http://www.ebi.ac.uk/swissprot/) connects amino acid sequences with the current knowledge in the Life Sciences. Each protein entry provides an interdisciplinary overview of relevant information by bringing together experimental results, computed features and sometimes even contradictory conclusions. Detailed expertise that goes beyond the scope of SWISS-PROT is made available via direct links to specialised databases. SWISS-PROT provides annotated entries for all species, but concentrates on the annotation of entries from human (the HPI project) and other model organisms to ensure the presence of high quality annotation for representative members of all protein families. Part of the annotation can be transferred to other family members, as is already done for microbes by the High-quality Automated and Manual Annotation of microbial Proteomes (HAMAP) project. Protein families and groups of proteins are regularly reviewed to keep up with current scientific findings. Complementarily, TrEMBL strives to comprise all protein sequences that are not yet represented in SWISS-PROT, by incorporating a perpetually increasing level of mostly automated annotation. Researchers are welcome to contribute their knowledge to the scientific community by submitting relevant findings to SWISS-PROT at swiss-prot@expasy.org. Animals Archaeal Proteins/chemistry Bacterial Proteins/chemistry Databases, Protein Humans Information Storage and Retrieval Models, Animal Plant Proteins/chemistry Proteins/chemistry/classification Proteome/chemistry Proteomics Systems Integration Terminology as Topic Dewey 576 136 Département de biologie structurale et bioinformatique 21E false 283ea908-4a0f-403e-afca-454333963c49 Swiss-Prot Research Group 405b9ec3-ed88-49e8-9c17-4f861cf66d82 Swiss Institute of Bioinformatics (SIB) 57 Calipho 80 Nucleic acids research 31 1 2af7023c-3339-44e0-bd52-eed99ff3024b Article (Published version) Public pub_120_12520024.pdf 90719 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique

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