Protein sequence annotation in the genome era: the annotation concept of SWISS-PROT+TREMBL

Article Article scientifique Article Protein sequence annotation in the genome era: the annotation concept of SWISS-PROT+TREMBL eng 1997 author Apweiler Rolf author Gateau Alain 114432 author Contrino Sergio author Martin Maria J author Junker Viv 639309 author O'Donovan Claire author Lang Fiona author Mitaritonna Nicoletta author Kappus Stephanie author Bairoch Amos Marc 0000-0003-2826-6444 21964 33-43 9322012 1553-0833 SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation, a minimal level of redundancy and high level of integration with other databases. Ongoing genome sequencing projects have dramatically increased the number of protein sequences to be incorporated into SWISS-PROT. Since we do not want to dilute the quality standards of SWISS-PROT by incorporating sequences without proper sequence analysis and annotation, we cannot speed up the incorporation of new incoming data indefinitely. However, as we also want to make the sequences available as fast as possible, we introduced TREMBL (TRanslation of EMBL nucleotide sequence database), a supplement to SWISS-PROT. TREMBL consists of computer-annotated entries in SWISS-PROT format derived from the translation of all coding sequences (CDS) in the EMBL nucleotide sequence database, except for CDS already included in SWISS-PROT. While TREMBL is already of immense value, its computer-generated annotation does not match the quality of SWISS-PROTs. The main difference is in the protein functional information attached to sequences. With this in mind, we are dedicating substantial effort to develop and apply computer methods to enhance the functional information attached to TREMBL entries. Amino Acid Sequence Databases, Factual Genome Proteins/genetics Software Software Design Dewey 576 136 Département de biologie structurale et bioinformatique 21E false 283ea908-4a0f-403e-afca-454333963c49 Swiss-Prot Research Group 57 Calipho 80 Proceedings 5 525468ef-0600-49d5-ae07-e3f38b5d529b Article (Published version) Public pub_066_9322012.pdf 765829 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique

Title	Published in	Year	Views	Downloads

Technical comment to "Database verification studies of SWISS-PROT and GenBank" by Karp et al	Bioinformatics	2001	667	96
Protein sequence annotation in the genome era: the annotation concept of SWISS-PROT+TREMBL	Proceedings	1997	658	1,544

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Junker, Viv