Personality traits, cognition and volumetric MRI changes in elderly patients with early-onset depression: A 2-year follow-up study

Article Article scientifique Article Personality traits, cognition and volumetric MRI changes in elderly patients with early-onset depression: A 2-year follow-up study eng 2012 author Weber Kerstin Maud 106512 author Giannakopoulos Panteleimon 44657 author Delaloye Christophe 85403 author De Bilbao Fabienne 91197 author Moy Guenael 89335 author Ebbing Karsten 561687 author Moussa Abba 637242 author Herrmann François 70980 author Gold Gabriel 135308 author Canuto Alessandra 527017 47-52 10.1016/j.psychres.2011.11.017 22397914 0165-1781 Previous studies revealed personality changes in elderly patients with early-onset depression (EOD) that persist in euthymic stages. However, depression in older patients is a complex disorder that may affect not only personality, but also cognition and brain structure. To address this issue, a cross-sectional comparison and 2-year follow-up of 28 EOD elderly patients and 48 healthy controls included detailed neurocognitive assessment, estimates of brain volumes in limbic areas and white matter hyperintensities, as well as evaluation of the Five Factor Model of personality, in a remitted mood state. Results revealed that cognitive performances as well as brain volumes were preserved in EOD patients both at baseline and at follow-up. The increased Neuroticism factor and Anxiety facet scores as well as the decreased Warmth and Positive Emotions facet scores found at baseline reached the level of healthy controls after 2years. Only the Depression facet scores remained significantly higher in EOD patients compared to controls upon follow-up. Results were independent of depressive relapse since baseline (25% of patients). These findings suggest that both cognitive performances and brain volumes show long-term preservation in older EOD patients. In contrast, the depression-related personality facet might be a trait like marker that persists in the long-term evolution of this disorder. Aging Cognition Imaging Temperament Affective disorder Follow-up study Dewey 616.89 Dewey 618.97 60 Département de psychiatrie 225 65 Département de réadaptation et gériatrie 22B false 312 Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive 577 Psychiatry research 198 1 52c1ab23-de8a-4e81-a91b-a4a8f935ea99 Article (Published version) Restricted PersonalityTraitsDelaloye.pdf 168002 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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Personality traits, cognition and volumetric MRI changes in elderly patients with early-onset depression: A 2-year follow-up study	Psychiatry research			2012	652	0

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