High efficiency production and purification of 86Y based on electrochemical separation

Article Article scientifique Article High efficiency production and purification of 86Y based on electrochemical separation eng 2009 author Lukic Dragoljub 637036 author Tamburella Claire author Buchegger Franz 124544 author Beyer Gerd-Jurgen 29756 author Comor Jozef J. author Seimbille Yann 640596 523-529 10.1016/j.apradiso.2008.12.008 19181533 0969-8043 http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271878&_user=9565874&_pii=S0969804308005526&_check=y&_origin=article&_zone=toolbar&_coverDate=30-Apr-2009&view=c&originContentFamily=serial&wchp=dGLzVlV-zSkWA&md5=d84285393b0d1bb73f079a6038273047/1-s2.0-S0969804308005526-main.pdf As an intermediate half-life positron emitter (86)Y is an attractive radioisotope for positron emission tomography (PET) studies, particularly for patient specific dosimetry planning of (90)Y-based radiotherapy procedures. It can be conveniently produced by a small-sized cyclotron via the (86)Sr(p,n)(86)Y nuclear reaction. The optimization of the electrochemical separation of (86)Y from the target material and its purification was done by modeling the whole production cycle using (90)Y. The radionuclide was isolated using four electrodes in two electrolytic steps. In the first step two Pt plate anodes and a Pt Winkler cathode were used and the electro-deposition yield was determined in constant current mode of operation. In addition, the influence of pH on the efficiency of this first step was investigated. The second electrolysis, with Winkler electrode as anode and a Pt wire as cathode, was also performed in constant current mode of operation. The kinetics of recovery of the deposited activity on the Pt wire was investigated in acidic solutions. The optimized electrochemical method was then applied for (86)Y separation and purification. This modified procedure was proved to be faster and simpler than the previously proposed electrochemical techniques and is more convenient for automation of the routine production of (86)Y. Dewey 616.0757 62 Département de radiologie et informatique médicale 227 false 177 Ciblage tumoral par anticorps, peptides et nucléotides radiomarqués 221 556 Cyclotron 897 Applied radiation and isotopes 67 4 98b97431-486b-491f-a9fd-581d0cca66f9 Article Restricted file1.pdf 1214128 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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High efficiency production and purification of 86Y based on electrochemical separation	Applied radiation and isotopes			2009	623	0

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