Genetic association of the Phosphoinositide-3 kinase in schizophrenia and bipolar disorder and interaction with a BDNF gene polymorphism

Article Article scientifique Article Genetic association of the Phosphoinositide-3 kinase in schizophrenia and bipolar disorder and interaction with a BDNF gene polymorphism eng 2011 author Carrard Anthony 597638 author Salzmann Annick 0000-0003-0571-251X 510521 author Perroud Nader Ali 0000-0002-9282-9216 94458 author Gafner Jeremie Yves 633727 author Malafosse Alain 111681 author Karege Félicien 61553 119-124 10.1002/brb3.23 22399091 2162-3279 Phosphoinositide-3-kinase, class III (PIK3C3) is a member of the phosphoinosite-3-kinases family, involved in cell signaling, membrane trafficking, and neurodevelopment. Previous studies have indeed shown an association between PIK3C3 gene variants and both bipolar disorder (BD) and schizophrenia (SZ). Brain-derived neurotrophic factor (BDNF) is a neurodevelopmental factor, which can regulate the PI3K signaling pathway. Associations have been reported between BDNF gene polymorphisms and affective and psychotic disorders. The aim of the present study was to replicate an association between PIK3C3 and BDNF gene variants in SZ and BD and a putative epistasis between the two genes. Patients meeting the DSM-IV criteria of BD and SZ were included in this study (98 BD and 79 SZ) as well as 158 healthy controls. Blood DNA was extracted and genotyping was performed either by the polymerase chain reaction (PCR) technique followed by enzymatic digestion or by the high-resolution melt (HRM) method. Genotype and haplotype association was assessed with the UNPHASED statistical program.The results showed one nominal association with BD (P < 0.02) and two risk haplotypes in both SZ (P < 0.001) and BP (P < 0.0005), which survived multiple testing correction. A modest interaction between a BDNF variant and PI3KC3 polymorphism was observed (P < 0.04).These preliminary results confirm the genetic association of PI3K gene variants with both SZ and BD, and support the hypothesis that SZ and BD share a genetic background. Dewey 616.89 60 Département de psychiatrie 225 false 4 Génétique psychiatrique 4 Brain and behavior 1 2 97dee643-874b-449b-a7c7-757314fc7e00 Article (Published version) Public brb30001-0119.pdf 122389 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Genetic association of the Phosphoinositide-3 kinase in schizophrenia and bipolar disorder and interaction with a BDNF gene polymorphism	Brain and behavior			2011	697	594

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Gafner, Jeremie Yves