Telomeric rather than centromeric activating KIR genes protect from cytomegalovirus infection after kidney transplantation

Article Article scientifique Article Telomeric rather than centromeric activating KIR genes protect from cytomegalovirus infection after kidney transplantation eng 2011 author Stern M author Hadaya Karine 34570 author Hönger G author Martin Pierre-Yves 65591 author Steiger Jeannette 51461 author Hess C author Villard Jade 633561 1302-1307 10.1111/j.1600-6143.2011.03516.x 21486386 1600-6135 Cytomegalovirus (CMV) infection is a common complication after organ transplantation. Previous studies have demonstrated that activating killer-cell immunoglobulin-like receptors (KIR) may reduce the rate of CMV infection. KIR genes can be divided into haplotype A (containing a fixed set of inhibitory receptors) and haplotype B (carrying additional activating KIR genes). The KIR locus is divided into a centromeric and a telomeric portion, both of which may carry A or B haplotype motifs. We studied a cohort of 339 kidney transplant recipients to elucidate which KIR genes protect from CMV infection. CMV infection occurred in 139 patients (41%). Possession of telomeric (hazard ratio 0.64, 95% confidence interval 0.44-0.94, p = 0.02) but not centromeric (HR 0.86, 95% CI 0.60-1.23, p = 0.41) B motifs was associated with statistically significant protection from CMV infection. Due to linkage disequilibrium, we were not able to identify a single protective gene within the telomeric B complex (which may contain the KIR2DS1, KIR3DS1, KIR2DL5A and KIR2DS5 genes). The presence of known or putative ligands to activating KIR did not significantly modify the influence of telomeric B group genes. We confirm that B haplotypes protect from CMV infection after kidney transplantation and show that this arises from telomeric B haplotype genes. Adolescent Adult Aged Aged, 80 and over Centromere Child Child, Preschool Cohort Studies Cytomegalovirus Infections/prevention & control Female Humans Kidney Transplantation/adverse effects Male Middle Aged Receptors, KIR/genetics Telomere Young Adult Dewey 616 56 Département de médecine 221 false 298 Immunologie de transplantation, immunogénétique et thérapie cellulaire 561 American journal of transplantation 11 6 44098d04-d363-4e04-b916-12f2b3e59326 Article (Published version) Restricted Villard et al AMJT III.x.pdf 177705 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Telomeric rather than centromeric activating KIR genes protect from cytomegalovirus infection after kidney transplantation	American journal of transplantation			2011	653	0

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Villard, Jade