Shear-stress sensitive lenticular vesicles for targeted drug delivery

Article Article scientifique Article Shear-stress sensitive lenticular vesicles for targeted drug delivery eng 2012 author Holme Margaret Nancy 711706 author Fedotenko Illya 678706 author Abegg Daniel 646062 author Althaus Jasmin author Babel Lucille author Favarger France 22133 author Reiter Renate author Tanasescu Radu 633557 author Zaffalon Pierre Léonard 596396 author Ziegler André author Müller Bert author Saxer Till Alexandre 503485 author Zumbuehl Andréas 668486 536-543 10.1038/nnano.2012.84 1748-3387 Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles made from an artificial 1,3-diaminophospholipid are stable under static conditions but release their contents at elevated shear stress. These vesicles have a lenticular morphology, which potentially leads to instabilities along their equator. Using a model cardiovascular system based on polymer tubes and an external pump to represent shear stress in healthy and constricted vessels of the heart, we show that drugs preferentially release from the vesicles in constricted vessels that have high shear stress. Dewey 540 Dewey 616 36 Département de chimie organique 141 56 Département de médecine 221 false Nature nanotechnology 7 8 efb1e43e-73d2-4e3c-b589-bcf45ba3f62b Article (Published version) Restricted nnano.2012.84.pdf 3524354 application/pdf restrictedAccess Faculté des sciences / Section de chimie et biochimie / Département de chimie organique Faculté de médecine / Section de médecine clinique / Département de médecine

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