Intravenous iron supplementation after liver surgery: Impact on anemia, iron, and hepcidin levels-a randomized controlled trial

Article Article scientifique Article Intravenous iron supplementation after liver surgery: Impact on anemia, iron, and hepcidin levels-a randomized controlled trial eng 2021 author Assouline Benjamin 595385 author Benoliel Alan author Zamberg Ido 804156 author Legouis David 883952 author Delhumeau-Cartier Cécile 514342 author Favre Mathieu 631040 author Andres Axel 105988 author Toso Christian 0000-0003-1652-4522 92271 author Samii Kaveh 24652 author Schiffer Eduardo 0000-0002-7415-4315 33705 813-821 10.1016/j.surg.2021.03.020 33888314 0039-6060 https://www.sciencedirect.com/science/article/pii/S0039606021002129 Anemia is a recognized risk factor for perioperative related morbidity and mortality and is frequently reported in liver surgeries with an estimated incidence of 32%. We aim to assess the impact of intravenous iron administration in the immediate postoperative period on anemia and iron status as well as to determine the kinetics of hepcidin after liver surgery. Methods: The HepciFer trial, a randomized controlled trial, included 50 patients undergoing liver surgery. In accordance with the randomization process, patients received either ferric carboxymaltose (15 mg/kg, maximum 1 g) or placebo 4 hours after surgery. Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 562 Transplantation et hépatologie 905 Surgery 170 3 7b50037e-0e37-4e70-a2a1-bfbe9ede237e Article (Published version) Public 1-s2.0-S0039606021002129-main(1).pdf 680437 application/pdf CC BY-NC-ND ef31d160-ab29-4cb8-8d01-cbbcc269f3b9 Supplemental data Public 1-s2.0-S0039606021002129-mmc1.docx 26515 application/vnd.openxmlformats-officedocument.wordprocessingml.document openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Intravenous iron supplementation after liver surgery: Impact on anemia, iron, and hepcidin levels-a randomized controlled trial	Surgery			2021	288	301

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Favre, Mathieu