The insulin/IGF system in mammalian sexual development and reproduction

Article Article scientifique Revue de la littérature The insulin/IGF system in mammalian sexual development and reproduction eng 2019 author Neirijnck Yasmine 834332 author Papaioannou Maria-Eleni 628532 author Nef Serge 0000-0001-5462-0676 29062 E4440 10.3390/ijms20184440 31505893 1661-6596 Persistent research over the past few decades has clearly established that the insulin-like family of growth factors, which is composed of insulin and insulin-like growth factors 1 (IGF1) and 2 (IGF2), plays essential roles in sexual development and reproduction of both males and females. Within the male and female reproductive organs, ligands of the family act in an autocrine/paracrine manner, in order to guide different aspects of gonadogenesis, sex determination, sex-specific development or reproductive performance. Although our knowledge has greatly improved over the last years, there are still several facets that remain to be deciphered. In this review, we first briefly outline the principles of sexual development and insulin/IGF signaling, and then present our current knowledge, both in rodents and humans, about the involvement of insulin/IGFs in sexual development and reproductive functions. We conclude by highlighting some interesting remarks and delineating certain unanswered questions that need to be addressed in future studies. Dewey 576.5 Swiss National Science Foundation Revisiting adreno-gonadal development and cell fate commitment using single cell RNA sequencing 173070 CH Project funding Swiss National Science Foundation 51PHI0-141994 CH 135 Département de médecine génétique et développement 21D false 448 Mécanismes moléculaires et génétiques du développement sexuel 778 International Journal of Molecular Sciences 20 18 22d85078-0d28-45fa-b023-45aa098077b2 Article (Published version) Public NeirjnckIGFs.pdf 2190157 application/pdf CC BY openAccess Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

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The insulin/IGF system in mammalian sexual development and reproduction	International Journal of Molecular Sciences			2019	333	177

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Papaioannou, Maria-Eleni