Prevalence and factors associated with severe fatigue 2 years into the COVID-19 pandemic : a cross-sectional population-based study in Geneva, Switzerland

Article Article scientifique Article Prevalence and factors associated with severe fatigue 2 years into the COVID-19 pandemic : a cross-sectional population-based study in Geneva, Switzerland eng 2025-01-08 2025-01-08 author Graindorge Clément 0009-0002-7212-1058 Unit of Population Epidemiology, Division of Primary Care Medicine, HUG, Geneva, Switzerland clement.graindorge@hug.ch. 715410 author Schrempft Stéphanie Unit of Population Epidemiology, Division of Primary Care Medicine, HUG, Geneva, Switzerland. 931965 author Pullen Nick Unit of Population Epidemiology, Division of Primary Care Medicine, HUG, Geneva, Switzerland. author Baysson Hélène 0000-0003-4676-4500 Unit of Population Epidemiology, Division of Primary Care Medicine, HUG, Geneva, Switzerland. 927962 Hélène BAYSSON author Zaballa Maria Eugenia Unit of Population Epidemiology, Division of Primary Care Medicine, HUG, Geneva, Switzerland. author Stringhini Silvia Unit of Population Epidemiology, Division of Primary Care Medicine, HUG, Geneva, Switzerland.,Faculty of Medicine, University of Geneva, Geneva, Switzerland. 830749 Médecine de premier recours hospitalo-universitaire (MPRHU) author Nehme Mayssam Unit of Population Epidemiology, Division of Primary Care Medicine, HUG, Geneva, Switzerland. 840942 Département de santé et médecine communautaire (MECOM) author Guessous Idris Unit of Population Epidemiology, Division of Primary Care Medicine, HUG, Geneva, Switzerland.,Faculty of Medicine, University of Geneva, Geneva, Switzerland. 760565 Médecine de premier recours hospitalo-universitaire (MPRHU) Specchio-COVID19 study group collaborator Arm-Vernez Isabelle 690605 collaborator Azman Andrew 0000-0001-8662-9077 954616 collaborator Bachmann Delphine 660855 collaborator Bal Antoine collaborator Balavoine Jean-François 23999 collaborator Barbe Remy 527289 collaborator Berthelot Julie collaborator Bouhet Aminata Rosalie 941428 collaborator Bryand Gaelle 133381 collaborator Chappuis François 34709 Département de santé et médecine communautaire (MECOM) collaborator Collombet Prune 930845 collaborator Coudurier-Boeuf Sophie 713250 collaborator Courvoisier Delphine 0000-0002-1956-2607 94475 Département de médecine (DEMED) collaborator De Mestral Carlos collaborator D'ippolito Paola collaborator Dubos Richard collaborator Dumont Roxane 822214 collaborator El Merjani Nacira collaborator Flahault Antoine 815316 Institut de santé globale (COSPR) collaborator Francioli Nathalie collaborator Harnal Severine 417938 collaborator Hurst Samia 0000-0002-1980-5226 84281 iEH2 (COETH) collaborator Kaiser Laurent 28229 Département de médecine (DEMED) collaborator Kathari Gabriel collaborator Kherad Omar 509928 Département de médecine (DEMED) collaborator Lamour Julien collaborator Lescuyer Pierre 0000-0001-6986-8738 562350 collaborator L'Huillier Arnaud 0000-0001-9230-7285 543058 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) collaborator Loizeau Andréa 677311 collaborator Lorthe Elsa Louise Adèle 416911 collaborator Martinez Chantal 591418 collaborator Mechoullam Shannon 818134 collaborator Metral-Boffod Ludovic 647651 collaborator Noël Natacha collaborator Pennacchio Francesco collaborator Perez-Saez Javier collaborator Pittet Didier 117792 Décanat et administration de la faculté de médecine (ADMED) collaborator Posfay Barbe Klara 39230 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) collaborator Poulain Géraldine 868190 collaborator Pugin Caroline 926418 collaborator Richard Viviane Adissa 899625 collaborator Rochat Michèle Deborah 83757 collaborator Rouzinov Sergei collaborator Samir Khadija 417937 collaborator Santa-Ramirez Hugo 0000-0001-7535-9171 943645 collaborator Satin Etienne collaborator Schaller Philippe 42706 collaborator Semaani Claire collaborator Testini Stéphanie 808001 collaborator Uppal Anshu 689182 collaborator Urrutia Rivas Deborah 840320 collaborator Verolet Charlotte 646895 collaborator Vetter Pauline 673142 collaborator Villers Jennifer Annick M. 941947 Département de pathologie et immunologie (PATIM) collaborator Violot Guillemette collaborator Vuilleumier Nicolas 61406 Département de médecine (DEMED) collaborator Wisniak Ania 717179 collaborator Yerly Ferrillo Sabine 23752 collaborator Zimmermann Olivier 598957 e089011 10.1136/bmjopen-2024-089011 39779264 2044-6055 PMC11749439 https://bmjopen.bmj.com/content/15/1/e089011.long Objectives: This study aims (1) to assess the prevalence of severe fatigue among the general population of Geneva, 2 years into the COVID-19 pandemic and (2) to identify pandemic and non-pandemic factors associated with severe fatigue. Design: Cross-sectional population-based survey conducted in Spring 2022. Setting: General adult population of Geneva, Switzerland. Participants: 6870 adult participants, randomly selected from the general population, included in the Specchio-COVID-19 cohort study, were invited to answer an online health survey. Outcome and cofactor measure: Prevalence of severe fatigue was measured by the Chalder Fatigue Questionnaire with a cut-off score≥4 out of 11. We assessed prevalence ratios of severe fatigue considering sociodemographic factors, health and behavioural characteristics (body mass index, depression, recent diagnosis of chronic disease or allergy, acute health event, smoking status, physical activity and sleep quality) and recent self-reported COVID-19 infections. Results: A total of 4040 individuals participated (participation rate 59%, 58% were women, mean age 53.2 (SD=14.1 years)). Overall prevalence of severe fatigue was 30.7% (95% CI=29.2%-32.1%). After adjusting for age, sex, educational level and pre-existing comorbidities, the following characteristics were associated with severe fatigue: individuals aged 18-24 years (adjusted prevalence ratio (aPR)=1.39 (1.10-1.76)) and 25-34 years (aPR=1.23 (1.05-1.45)), female sex (aPR=1.28 (1.16-1.41)), depression (aPR=2.78 (2.56-3.01)), occurrence of health events unrelated to COVID-19 (aPR=1.51 (1.38-1.65)) and self-reported COVID-19 infection in the past 12 months (aPR=1.41 (1.28-1.56)). After further adjustment for depression, previous associations were maintained except for young age. Conclusions: About one-third of the adult general population of Geneva experienced severe fatigue, 2 years into the COVID-19 pandemic. Heightened fatigue among young adults is partly explained by depressive symptoms. Recent COVID-19 infection is substantially associated with severe fatigue, regardless of infection severity or co-occurrence of depressive disorder. Trial registration number: CCER project ID 2020-00881. COVID-19 Fatigue Prevalence Humans COVID-19 / epidemiology Switzerland / epidemiology Fatigue / epidemiology Female Male Cross-Sectional Studies Middle Aged Adult SARS-CoV-2 Aged Young Adult Risk Factors Adolescent Pandemics Depression / epidemiology Dewey 174.957 Dewey 613 Dewey 616 Dewey 618 56 Département de médecine 221 201 Centre de médecine de premier recours 22A9 58 Département de pédiatrie, gynécologie et obstétrique 223 66 Institut de santé globale 22A1 69 Institut Ethique Histoire Humanités 22A6 false 211 Auto-immunité, inflammation et athérosclérose 270 1313 Médecine de 1er recours 1020 453 Ethique biomédicale 783 400 Virologie clinique 668 907 Groupe Flahault Antoine 945 251 Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière 330 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 BMJ open 15 1 a98a60da-90c3-4ab6-bbe1-0b92c8216f58 Article (Published version) Public Article_scientifique_from_europePmc.pdf 1326538 application/pdf CC BY-NC-4.0 df3872c3b8ea93e272e675f7096bf79fb5f07b07d096c07f055e01de00ae77e7 88257ab8-f2ce-40b3-bf7d-d90d0a577539 Appendix Public bmjopen-15-1-s001.pdf 86172 application/pdf a4888af0fd85ad3cc78382dc8521be902e5d8d004a4b3e011e0698e56b8c5680 360315aa-ba51-47fb-a0f8-37a652322df9 Appendix Public bmjopen-15-1-s002.pdf 100157 application/pdf da343d9b84f02fb76018e0890b7aa34de3f1db0a23da9b9cdbc30f991e629fb3 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Centre de médecine de premier recours Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de santé globale Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut Ethique Histoire Humanités

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Prevalence and factors associated with severe fatigue 2 years into the COVID-19 pandemic : a cross-sectional population-based study in Geneva, Switzerland	BMJ open			2025	111	277

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Zimmermann, Olivier