Effect of inspired CO₂ on the ventilatory response to high intensity exercise

Article Article scientifique Article Effect of inspired CO₂ on the ventilatory response to high intensity exercise eng 2012 author Fan Jui-Lin 731307 author Leiggener Christian 597575 author Rey Florian 631947 author Kayser Bengt E. 0000-0002-9776-7501 24108 283-288 10.1016/j.resp.2011.12.004 22198479 1569-9048 We tested the hypothesis that preventing the poikilocapnic response to high intensity exercise would increase the ventilatory response to exercise. We measured ventilatory variables in 10 healthy men during incremental cycling with and without inspired CO(2) (randomised order). Inspired CO(2) elevated resting ventilation (V(E)), tidal volume (V(T)), PETCO₂ and PETO₂ by 5 ± 5 L/min, 0.3 ± 0.2 L, 6 ± 3 mm Hg and 11 ± 7 mm Hg, respectively (P<0.05); resting breathing frequency (f), expired CO(2) (VCO₂) and O(2) consumption (VO₂) remained similar (P>0.05). During high intensity exercise, inspired CO(2) elevated PETCO₂ by 7 ± 2, 10 ± 4 and 11 ± 4 mm Hg at 80%, 90% and 100% VO₂ max, respectively (P<0.01), while PETCO₂ remained unchanged (P>0.05). During high intensity exercise, inspired CO(2) elevated VT by 0.2 ± 0.3 L at 80%, 90% and 100% VO₂ max, respectively (P<0.05), while no differences were observed in V(E), f, VO₂, or power output (P>0.05). These data suggest a progressively diminishing role of CO(2) chemoreception in the control of ventilation during maximal incremental exercise. Administration, Inhalation Adult Anaerobic Threshold/physiology Bicycling/physiology Carbon Dioxide/administration & dosage/pharmacology Data Interpretation, Statistical Exercise/physiology Exercise Test Heart Rate/physiology Humans Hypocapnia/physiopathology Male Oxygen Consumption/physiology Perception/physiology Physical Exertion/physiology Pulmonary Gas Exchange/physiology Pulmonary Ventilation/drug effects Tidal Volume/physiology Young Adult Dewey 616.9802 52 Ecole d'éducation physique et de sport 27 false 236 Groupe Kayser Bengt (médecine du sport) 306 Respiratory physiology & neurobiology 180 2-3 f995e114-0294-4be6-b00d-8c7212bdcc5e Article (Published version) Restricted ventil resp co2.pdf 383872 application/pdf restrictedAccess Faculté de médecine / Ecole d'éducation physique et de sport

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Effect of inspired CO₂ on the ventilatory response to high intensity exercise	Respiratory physiology & neurobiology			2012	652	0

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Leiggener, Christian