Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP/ORCA workshop on the boundaries between caries and periodontal disease

Article Article scientifique Article Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP/ORCA workshop on the boundaries between caries and periodontal disease fre 2017 author Sanz Mariano author Beighton David author Curtis Michael A. author Cury Jaime A. author Dige Irene author Dommisch Henrik author Ellwood Roger author Giacaman Rodrigo A. author Herrera David author Herzberg Mark C. author Könönen Eija author Marsh Philip D. author Meyle Joerg author Mira Alex author Molina Herrera Ana Cristina 596166 author Mombelli Andrea 128580 author Quirynen Marc author Reynolds Eric C. author Shapira Lior author Zaura Egija S5-S11 10.1111/jcpe.12682 0303-6979 BACKGROUND AND AIMS: The scope of this working group was to review (1) ecological interactions at the dental biofilm in health and disease, (2) the role of microbial communities in the pathogenesis of periodontitis and caries, and (3) the innate host response in caries and periodontal diseases. RESULTS AND CONCLUSIONS: A health-associated biofilm includes genera such as Neisseria, Streptococcus, Actinomyces, Veillonella and Granulicatella. Microorganisms associated with both caries and periodontal diseases are metabolically highly specialized and organized as multispecies microbial biofilms. Progression of these diseases involves multiple microbial interactions driven by different stressors. In caries, the exposure of dental biofilms to dietary sugars and their fermentation to organic acids results in increasing proportions of acidogenic and aciduric species. In gingivitis, plaque accumulation at the gingival margin leads to inflammation and increasing proportions of proteolytic and often obligately anaerobic species. The natural mucosal barriers and saliva are the main innate defence mechanisms against soft tissue bacterial invasion. Similarly, enamel and dentin are important hard tissue barriers to the caries process. Given that the present state of knowledge suggests that the aetiologies of caries and periodontal diseases are mutually independent, the elements of innate immunity that appear to contribute to resistance to both are somewhat coincidental. *caries *dental biofilm *dysbiosis *innate host responses *microbial interactions *periodontal diseases *symbiosis Dewey 617.6 206 Division de paradontologie 24P2 false Journal of Clinical Periodontology 44 4d374168-eef8-4993-ae89-9ca98b2478ab Article (Published version) Restricted Sanz_et_al-2017-Journal_of_Clinical_Periodontology.pdf 275266 application/pdf restrictedAccess Faculté de médecine / Section de médecine dentaire / Département de médecine dentaire préventive et de premier recours / Division de paradontologie

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Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP/ORCA workshop on the boundaries between caries and periodontal disease	Journal of Clinical Periodontology			2017	522	0

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Molina Herrera, Ana Cristina