Membrane fission by dynamin: what we know and what we need to know

Article Article scientifique Article Membrane fission by dynamin: what we know and what we need to know eng 2016 author Antonny Bruno author Burd Christopher author De Camilli Pietro author Chen Elizabeth author Daumke Oliver author Faelber Katja author Ford Marijn author Frolov Vadim A author Frost Adam author Hinshaw Jenny E author Kirchhausen Tom author Kozlov Michael M author Lenz Martin author Low Harry H author McMahon Harvey author Merrifield Christien author Pollard Thomas D author Robinson Phillip J author Roux Aurélien 0000-0002-6088-0711 716946 author Schmid Sandra 593835 2270-2284 10.15252/embj.201694613 0261-4189 https://onlinelibrary.wiley.com/doi/abs/10.15252/embj.201694613 The large GTPase dynamin is the first protein shown to catalyze membrane fission. Dynamin and its related proteins are essential to many cell functions, from endocytosis to organelle division and fusion, and it plays a critical role in many physiological functions such as synaptic transmission and muscle contraction. Research of the past three decades has focused on understanding how dynamin works. In this review, we present the basis for an emerging consensus on how dynamin functions. Three properties of dynamin are strongly supported by experimental data: first, dynamin oligomerizes into a helical polymer; second, dynamin oligomer constricts in the presence of GTP; and third, dynamin catalyzes membrane fission upon GTP hydrolysis. We present the two current models for fission, essentially diverging in how GTP energy is spent. We further discuss how future research might solve the remaining open questions presently under discussion. Dewey 540 39 Département de biochimie 144 false EMBO Journal 35 21 badee197-aa71-4574-bb8e-2fdaa0241925 Article (Published version) Public MembraneAR_16.pdf 8261041 application/pdf openAccess Faculté des sciences / Section de chimie et biochimie / Département de biochimie

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Membrane fission by dynamin: what we know and what we need to know	EMBO Journal	2016	319	125
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Schmid, Sandra