Effect of islet alone or islets after kidney transplantation on quality of life in type 1 diabetes : systematic review

Article Article scientifique Revue de la littérature Effect of islet alone or islets after kidney transplantation on quality of life in type 1 diabetes : systematic review eng 2024-06-21 2024-12 author Gariani Karim Division of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland. Electronic address: karim.gariani@hcuge.ch. 542849 Département de médecine (DEMED) author Peloso Andréa 0000-0002-3089-0230 Division of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland. 878393 Département de chirurgie (CHIRU) author Galani Vasiliki Service of Liaison Psychiatry and Crisis Intervention, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland. 848619 author Haidar Fadi Division of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland; Division of Nephrology and Hypertension, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. 960279 author Wassmer Charles-Henri Division of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland. 683357 Département de chirurgie (CHIRU) author Kumar Rohan Division of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland. author Holmgren Erika Division of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland. 586999 author Olivier Valérie 0000-0001-9308-4853 Division of Nephrology and Hypertension, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland; Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. 889276 Département de médecine (DEMED) author Prada Paco Boris Service of Liaison Psychiatry and Crisis Intervention, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland. 506849 Département de psychiatrie (PSYAT) author Compagnon Philippe Division of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland. 894594 Département de chirurgie (CHIRU) author Berishvili Berney Ekaterine 0000-0002-7969-1937 Division of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland; Cell Isolation and Transplantation Centre, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland; Department of Surgery, Laboratory of Tissue Engineering and Organ Regeneration, University of Geneva, Geneva, Switzerland; Ilia State University School of Medicine, Tbilisi, Georgia. 826237 Département de chirurgie (CHIRU) author Berney Thierry Cell Isolation and Transplantation Centre, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland; Ilia State University School of Medicine, Tbilisi, Georgia; Division of Nephrology, Immunology and Transplantation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France. 63319 Décanat et administration de la faculté de médecine (ADMED) 100870 10.1016/j.trre.2024.100870 38917621 0955-470X https://linkinghub.elsevier.com/retrieve/pii/S0955470X24000533 Background: Pancreatic islet transplantation for type 1 diabetes mellitus (T1DM) is efficacious in supressing severe hypoglycaemic episodes (SHE) and restoring glycaemic regulation, which are both pivotal in increasing health-related quality of life (HRQoL). Therefore, a systematic assessment of reports detailing HRQoL outcomes is warranted to better understand the benefits of islet transplantation. To this end, we performed a systematic review of the literature to assess the impact of islet transplantation on HRQoL in individuals with T1DM, whether as a standalone procedure (ITA) or following renal transplantation (IAK). Method: All studies providing a quantitative assessment of HRQoL following ITA or IAK were included. Selected studies had to meet the following criteria: they had to (i) involve adult recipients of islet grafts for T1DM, (ii) use either generic or disease-specific QoL assessment tools, (iii) provide a comparative analysis of QoL metrics between the pre- and post-transplantation state or between the post-transplantation state and other pre-transplant patients or the general population. Results: Seven studies that met the inclusion criteria provided data on 205 subjects. In the included studies, HRQoL was measured using both generic instruments, such as the 36-item Short Form Health Survey (SF-36) and the Health Status Questionnaire (HSQ) 2.0, and disease-specific instruments, such as the Diabetes Distress Scale (DDS), the Diabetes Quality of Life Questionnaire, and the Hypoglycaemia Fear Survey (HFS). These instruments cover physical, mental, social, or functional health dimensions. We found that pancreatic islet transplantation was associated with improvements in all HRQoL dimensions compared with the pre-transplant baseline. Conclusions: Our systematic review demonstrates that islet transplantation significantly enhances quality of life in individuals with T1DM who are experiencing SHE. To our knowledge, this is the most extensive systematic review conducted to date, evaluating the impact of islet transplantation on HRQoL. Diabetes Islet transplantation Quality of life Systematic review Dewey 616.89 Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 60 Département de psychiatrie 225 false 1323 Création de tissus par bio-ingénieurie et régénération d'organes 1021 562 Transplantation et hépatologie 905 20 Laboratoire de physiologie et pathophysiologie des cellules rénales 29 357 La transplantation d'îlots de Langerhans 623 Transplantation reviews 38 4 c1ed05b7-72fb-4480-a369-023f6d68a840 Article (Published version) Public 1-s2.0-S0955470X24000533-main.pdf 421366 application/pdf CC BY-4.0 99151433ee869e3039e8b61d8902a5eebcebca94160a72c136816283a2f18ef1 58993125-b99d-4b48-9f9f-09d9c1c6dfb6 Supplemental data Public 1-s2.0-S0955470X24000533-mmc1.docx 23619 application/vnd.openxmlformats-officedocument.wordprocessingml.document 2f30588069b201eefb3e1ce8f37bf201935c153bfd4aae87c3bd9c874e27de03 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Effect of islet alone or islets after kidney transplantation on quality of life in type 1 diabetes : systematic review	Transplantation reviews			2024	73	332

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Holmgren, Erika