Connexins in vascular physiology and pathology

Article Article scientifique Article Connexins in vascular physiology and pathology eng 2009 author Brisset Anne-Cécile 586756 author Isakson Brant E. author Kwak Brenda 113350 267-282 10.1089/ars.2008.2115 18834327 1523-0864 Cellular interaction in blood vessels is maintained by multiple communication pathways, including gap junctions. They consist of intercellular channels ensuring direct interaction between endothelial and smooth muscle cells and the synchronization of their behavior along the vascular wall. Gap-junction channels arise from the docking of two hemichannels or connexons, formed by the assembly of six connexins, and achieve direct cellular communication by allowing the transport of small metabolites, second messengers, and ions between two adjacent cells. Physiologic variations in connexin expression are observed along the vascular tree, with most common connexins being Cx37, Cx40, and Cx43. Changes in the level of expression of connexins have been correlated to the development of vascular disease, such as hypertension, atherosclerosis, or restenosis. Recent studies on connexin-deficient mice highlighted key roles of these communication pathways in the development of these pathologies and confirmed the need for targeted pharmacologic approaches for their prevention and treatment. The aim of this issue is to review the current knowledge on the implication of gap junctions in vascular function and most common cardiovascular diseases. Animals Cell Communication Connexins/genetics/*metabolism/*physiology Endothelium, Vascular/*metabolism/physiopathology Gap Junctions/metabolism/physiology Humans Mice Muscle, Smooth, Vascular/*metabolism/physiopathology Vascular Diseases/metabolism/pathology Dewey 616.07 137 Département de pathologie et immunologie 21F false 397 L'athérosclérose 665 Antioxidants & redox signaling 11 2 a4eb3353-157e-418c-9c91-bb565cbdd176 Article Restricted file1.pdf 491233 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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Connexins in vascular physiology and pathology	Antioxidants & redox signaling			2009	532	0

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Brisset, Anne-Cécile