Antibiothérapie par voie sous-cutanée chez le patient âgé

Article Article professionnel Article Antibiothérapie par voie sous-cutanée chez le patient âgé fre Subcutaneous antibiotic administration in elderly patients 2014 author Gassler Vanessa 559562 author Stirnemann Jérôme 793435 author Csaki Huttner Angela 788122 author Prendki Virginie 0000-0003-1315-2938 811987 1924-1926 10.53738/REVMED.2014.10.446.1924 25438376 1660-9379 https://www.revmed.ch/revue-medicale-suisse/2014/revue-medicale-suisse-446/antibiotherapie-par-voie-sous-cutanee-chez-le-patient-age Although off-label, subcutaneous (SC) antibiotic administration is not infrequent, particularly among geriatric and palliative-care patients for whom other routes of administration are difficult to establish. Subcutaneous ceftriaxone is the most frequently prescribed antibiotic and it has been approved by some local committees given its favorable pharmacological parameters and relatively low subcutaneous toxicity. Yet pharmacologic and clinical data are lacking. No study has demonstrated non-inferiority of the subcutaneous route in comparison to other parenteral routes of administration. Randomized controlled trials are needed to assess the efficacy and tolerability of subcutaneous antibiotic administration given its frequent use in an aging population. Although off-label, subcutaneous (SC) antibiotic administration is not infrequent, particularly among geriatric and palliative-care patients for whom other routes of administration are difficult to establish. Subcutaneous ceftriaxone is the most frequently prescribed antibiotic and it has been approved by some local committees given its favorable pharmacological parameters and relatively low subcutaneous toxicity. Yet pharmacologic and clinical data are lacking. No study has demonstrated non-inferiority of the subcutaneous route in comparison to other parenteral routes of administration. Randomized controlled trials are needed to assess the efficacy and tolerability of subcutaneous antibiotic administration given its frequent use in an aging population. Age Factors Aged Aged, 80 and over Anti-Bacterial Agents/administration & dosage Antibiotic Prophylaxis/standards Humans Injections, Subcutaneous Dewey 618.97 65 Département de réadaptation et gériatrie 22B false 319 Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) 585 Revue médicale suisse 10 446 adedfb95-8f20-4ee8-9fff-f3f5f95d0e0a Article (Published version) Restricted RMS_446_1924.pdf 525777 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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Antibiothérapie par voie sous-cutanée chez le patient âgé	Revue médicale suisse			2014	467	0

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Gassler, Vanessa