Trends in antibiotic resistance of respiratory tract pathogens in children in Geneva, Switzerland

Article Article scientifique Article Trends in antibiotic resistance of respiratory tract pathogens in children in Geneva, Switzerland eng 2006 author Jaecklin Thomas 94281 author Rohner Peter 129742 author Jacomo Véronique 559182 author Schmidheiny Kurt author Gervaix Alain 31715 3-8 10.1007/s00431-005-1737-5 16133242 0340-6199 Bacteria increasingly resistant to antibiotics are a major treatment concern of respiratory tract pathogens in children. The aim of this study was to assess the trends of resistance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to several classes of antibiotics in children<16 years of age and to compare its prevalence with surrounding countries. We studied retrospectively the susceptibility of respiratory tract pathogens isolated from specimens collected from patients at the Geneva Children's Hospital between 1989 and 2004. The susceptibility of S. pneumoniae to penicillin decreased from 98% to 58% (P<0.001) within 16 years, mainly due to strains intermediately resistant (MICs 0.12-1.0 microg/ml). Also erythromycin-susceptible pneumococci decreased from 97% to 63% (P<0.001). The susceptibility of H. influenzae to amoxicillin also significantly declined (87% vs. 82%, P<0.001), and the susceptibility of M. catarrhalis to this drug almost disappeared (29% vs. 5%, P<0.001). However, in 2004 these two bacteria remained 100% susceptible to amoxicillin-clavulanic acid, second and third generation cephalosporins. Invasive H. influenzae strains were significantly more resistant to ampicillin than non-invasive strains, but no susceptibility difference between invasive and non-invasive S. pneumoniae was determined. Child Drug Resistance, Bacterial Female Haemophilus Infections/drug therapy/epidemiology/microbiology Haemophilus influenzae/drug effects Humans Male Microbial Sensitivity Tests Moraxella (Branhamella) catarrhalis/drug effects Moraxellaceae Infections/drug therapy/epidemiology/microbiology Prevalence Prospective Studies Respiratory Tract Infections/drug therapy/epidemiology/microbiology Retrospective Studies Streptococcal Infections/drug therapy/epidemiology/microbiology Streptococcus pneumoniae/drug effects Switzerland/epidemiology Dewey 613 Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 64 Département de santé et médecine communautaires 22A false 149 Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile 183 European journal of pediatrics 165 1 1c04512e-3c22-4b42-945f-4eb39e02f9e8 Article (Published version) Restricted 3-8.pdf 210742 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires

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Trends in antibiotic resistance of respiratory tract pathogens in children in Geneva, Switzerland	European journal of pediatrics			2006	479	0

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Jacomo, Véronique