Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice

Article Article scientifique Article Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice eng 2004 author Bernotiene Eiva 542705 author Palmer-Lourenco Gaby 0000-0001-7567-1798 45743 author Talabot Frischknecht-Ayer Dominique 133995 author Szalay Ildiko 24483 author Aubert Michel 25310 author Gabay Cem 70978 R256-263 10.1186/ar1174 15142272 1478-6354 The severity of antigen-induced arthritis (AIA) is decreased in leptin-deficient ob/ob mice. However, joint inflammation in AIA depends on the immune response, which is impaired in ob/ob mice. In the present study we investigated the effects of leptin deficiency on zymosan-induced arthritis (ZIA), which is independent of adaptive immunity. Arthritis was induced by injection of zymosan into the knee joint. Joint swelling was similar after 6 and 24 hours in ob/ob and control mice. However, it remained elevated in ob/ob animals on day 3 whereas values normalized in controls. Histology revealed similar articular lesions in all animals on day 3, but on days 14 and 21 arthritis tended to be more severe in ob/ob mice. The acute phase response, reflected by circulating levels of IL-6 and serum amyloid A, was also more pronounced in ob/ob mice, although corticosterone was significantly elevated in these animals. Similar results were obtained in leptin receptor-deficient db/db mice. Thus, in contrast to AIA, ZIA is not impaired in leptin-deficient animals. On the contrary, resolution of acute inflammation appears to be delayed in the absence of leptin or leptin signalling, suggesting that chronic leptin deficiency interferes with adequate control of the inflammatory response in ZIA. Acute Disease Acute-Phase Reaction/blood/etiology/genetics/pathology Animals Arthritis, Experimental/blood/chemically induced/complications/pathology Corticosterone/blood Cytokines/metabolism Edema/blood/etiology/genetics/pathology Inflammation/blood/etiology/metabolism/pathology Knee Joint/chemistry/drug effects/metabolism/pathology Leptin/deficiency/genetics/physiology Male Mice Mice, Inbred C57BL Mice, Mutant Strains RNA, Messenger/metabolism Receptors, Cell Surface/deficiency/physiology Receptors, Leptin Severity of Illness Index Zymosan/administration & dosage/pharmacology Dewey 616 Dewey 616.07 Dewey 618 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 58 Département de pédiatrie, gynécologie et obstétrique 223 false 28 Inflammation articulaire 44 Arthritis research & therapy 6 3 c735ff4d-060a-4df1-a2a3-7495ae419569 Article (Published version) Public ar1174.pdf 271971 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Title	Published in	Year	Views	Downloads

Inflammation aiguë persistante en réponse à l'injection intra-articulaire de Zymosan chez les souris déficientes en leptine ou en son récepteur		2005	1,250	959
Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice	Arthritis research & therapy	2004	493	186

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Bernotiene, Eiva