Mitochondria: regulating the inevitable

Article Article scientifique Article Mitochondria: regulating the inevitable eng 2002 author Parone Philippe 528921 author James Dominic 536902 author Martinou Jean-Claude 27293 105-111 10.1016/s0300-9084(02)01380-9 12022941 0300-9084 Apoptosis is a form of programmed cell death important in the development and tissue homeostasis of multicellular organisms. Abnormalities in cell death control can lead to a variety of diseases, including cancer and degenerative disorders. Hence, the process of apoptosis is tightly regulated through multiple independent signalling pathways that are initiated either from triggering events within the cell or at the cell surface. In recent years, mitochondria have emerged as the central components of such apoptotic signalling pathways and are now known to control apoptosis through the release of apoptogenic proteins. In this review we aim to give an overview of the role of the mitochondria during apoptosis and the molecular mechanisms involved. Apoptosis Mitochondria Bcl-2 Cytochrome c Apoptosis inducing factor Calcium Caspases Dewey 570 46 Département de biologie cellulaire 165 false Biochimie 84 2-3 fd710009-0dd9-4058-a335-c0ca026c8401 Article (Published version) Restricted P.A.Parone.pdf 179049 application/pdf restrictedAccess Faculté des sciences / Section de biologie / Département de biologie cellulaire

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Mitochondria: regulating the inevitable	Biochimie			2002	550	0

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James, Dominic