Turning telomeres off and on

Article Article scientifique Article Turning telomeres off and on eng 2001 author Dubrana Karine 533377 author Perrod Severine 134116 author Gasser Susan Margaret 133662 281-289 10.1016/S0955-0674(00)00210-6 0955-0674 https://linkinghub.elsevier.com/retrieve/pii/S0955067400002106 We envision multiple steps in telomere maintenance, based largely on genetic data from budding yeast. First, the telomere must unfold or open itself such that the free end is accessible to the appropriate enzymatic machinery. Second, telomerase must be recruited, together with the DNA replication machinery that synthesizes the C-rich strand. The processivity of telomerase is regulated both by a length-sensing feedback mechanism and by second-strand synthesis. Finally, the telosome refolds into a protective end structure. If telomerase is nonfunctional, recombination may occur once telomeres are open. Multiple pathways regulate these different steps, producing a highly dynamic chromosomal cap. Telomeres Telomerase CDC13 Checkpoint DNA replication TPE Silencing Nuclear organization Cell biology Genetics Dewey 570 43 Département de biologie moléculaire 161 false Current Opinion in Cell Biology 13 3 648b5fed-4aae-4f46-aceb-02fc4c2b066d Article (Published version) Restricted 1-s2.0-S0955067400002106-main.pdf 211669 application/pdf restrictedAccess Faculté des sciences / Section de biologie / Département de biologie moléculaire

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Turning telomeres off and on	Current Opinion in Cell Biology			2001	326	0

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Dubrana, Karine