Au-delà des antidépresseurs sérotoninergiques... nouvelles stratégies pharmacologiques

Article Article scientifique Revue de la littérature Au-delà des antidépresseurs sérotoninergiques... nouvelles stratégies pharmacologiques fre 2012 author Nicastro Letizia Stéphanie 632929 author Millet Philippe 0000-0002-5803-0478 668343 author Golaz Jean 526541 author Aubry Jean-Michel 32998 author Charnay Yves 526539 206-213 1661-3686 Although mood disorders such as depression are better diagnosed, their treatment often remains unsatisfactory. Pharmacological treatments of depression mostly target the central monoaminergic systems, especially serotonergic transmission. Various adverse effects (e.g. weight gain, nausea, headache, constipation), the relative inefficiency of the treatments (response rate no more than 50–60%) as well as the delay in the onset of therapeutic action represent some serious limitations. In addition to the improvement of selectivity of molecules available on the market and a better understanding of their mechanisms of action, other neurotransmitter systems that have received little attention so far are now being targeted for the treatment of depression. Glutamate receptor antagonists (e.g. ketamine, traxoprodil), nicotinic modulators (e.g. mecamylamine, varenicline), atypical antipsychotics (e.g. aripiprazole, quetiapine) possess antidepressant activity. The focus of the proposed research is to review recent developments in this field and the new prospects that it opens. Depression/anxiety Pharmacological approaches Recent Dewey 616.89 60 Département de psychiatrie 225 false 1221 Neuroimagerie moléculaire en psychiatrie 983 417 Thérapeutiques des Troubles de l'Humeur et Anxieux 689 Schweizer Archiv für Neurologie und Psychiatrie 163 6 e04d478e-7f2e-4cf3-9d4b-486f6c95697d Article (Published version) Restricted 2012-06-032.pdf 565448 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Au-delà des antidépresseurs sérotoninergiques... nouvelles stratégies pharmacologiques	Schweizer Archiv für Neurologie und Psychiatrie			2012	628	1

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Golaz, Jean