Effects of amygdala-hippocampal stimulation on interictal epileptic discharges

Article Article scientifique Article Effects of amygdala-hippocampal stimulation on interictal epileptic discharges eng 2012 author Tyrand Rémi 667521 author Seeck Margitta 133679 author Spinelli Laurent Jean-François 107347 author Pralong Emmanuel 525109 author Vulliemoz Serge 0000-0002-1877-8625 712268 author Foletti G author Rossetti A O author Allali Gilles 507314 author Lantz Goran 122552 author Pollo Claudio 36233 author Boex Colette 0000-0002-9374-4791 28086 87-93 10.1016/j.eplepsyres.2011.10.026 22079883 0920-1211 Deep brain stimulation (DBS) of different nuclei is being evaluated as a treatment for epilepsy. While encouraging results have been reported, the effects of changes in stimulation parameters have been poorly studied. Here the effects of changes of pulse waveform in high frequency DBS (130 Hz) of the amygdala-hippocampal complex (AH) are presented. These effects were studied on interictal epileptic discharge rates (IEDRs). AH-DBS was implemented with biphasic versus pseudo monophasic charge balanced pulses, in two groups of patients: six with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) and six with non lesional (NLES) temporal epilepsy. In patients with HS, IEDRs were significantly reduced with AH-DBS applied with biphasic pulses in comparison with monophasic pulse. IEDRs were significantly reduced in only two patients with NLES independently to stimulus waveform. Comparison to long-term seizure outcome suggests that IEDRs could be used as a neurophysiological marker of chronic AH-DBS and they suggest that the waveform of the electrical stimuli can play a major role in DBS. We concluded that biphasic stimuli are more efficient than pseudo monophasic pulses in AH-DBS in patients with HS. In patients with NLES epilepsy, other parameters relevant for efficacy of DBS remain to be determined. Adult Amygdala/physiology Deep Brain Stimulation/methods Epilepsy/physiopathology/therapy Female Hippocampus/physiology Humans Male Middle Aged Treatment Outcome Young Adult Dewey 616.8 61 Département des neurosciences cliniques 226 false 119 Epilepsie et Chirurgie 149 1279 Epilepsie et réseaux cérébraux 1002 Epilepsy research 99 1-2 3c3b145c-7a8c-4cc3-8c4c-bbd06f7272e2 Article (Published version) Restricted 1-s2.0-S0920121111003342-main.pdf 385840 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Effects of amygdala-hippocampal stimulation on interictal epileptic discharges	Epilepsy research			2012	563	0

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Pralong, Emmanuel