Tyrosine kinase drug discovery: what can be learned from solved crystal structures?

Article Article scientifique Article Tyrosine kinase drug discovery: what can be learned from solved crystal structures? eng 2006 author Moretti Loris 625257 author Tchernin Laura 524357 author Scapozza Leonardo 600318 38-49 10.3998/ark.5550190.0007.805 1551-7004 http://hdl.handle.net/2027/spo.5550190.0007.805 Understanding molecular recognition during ligand binding is crucial for rational drug design. Protein kinases are a well known pharmacological target, especially in the therapeutic area of cancer. Solved crystal structures of tyrosine kinase domains in complex with ligands deliver insight into the binding event. These experimental data were collected and analysed by means of molecular modelling techniques. Common molecular recognition patterns were depicted and studied among this class of proteins. The results of this analysis and the consequences for rational design of inhibitors are presented. Tyrosine kinase ligands Molecular modelling Ligand core Inhibitor minimal requirements and conserved ligand-kinase interactions Dewey 615 31 Section des sciences pharmaceutiques 17 false ARKIVOC 8 4be780cc-e955-4749-9893-17d34745fd49 Article (Published version) Public L.Moretti(1).pdf 271774 application/pdf openAccess Faculté des sciences / Section des sciences pharmaceutiques

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Tyrosine kinase drug discovery: what can be learned from solved crystal structures?	ARKIVOC			2006	564	462

Archive ouverte UNIGE

Tchernin, Laura