De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin

Article Article scientifique Article De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin eng 2006 author Rotman Samuel 115514 author Deruaz Cédric 519835 author Venetz Jean-Pierre author Chaubert Pascal author Benhattar Jean author Meuwly Jean-Yves 42937 author Jichlinski Patrice author Guillou Louis author Moll Solange 28349 author Pascual Manuel Antonio 23295 author Lemoine Robert 513772 481-487 10.1016/j.humpath.2005.11.024 16564925 0046-8177 In the general population, renal cell carcinoma (RCC) is a relatively common neoplasm; however, the papillary RCC subtype is infrequent and represents only 10 to 15% of all RCC. Angiomyolipoma is a well-known common benign tumor. The occurrence of RCC in association with angiomyolipoma is a rare event, with only approximately 50 cases reported in the nontransplantation setting. In transplant recipients, RCC can develop in native kidneys, but its occurrence "de novo" in the renal allograft is very rare with an estimated incidence of less than 0.5%. We report here the case of a 39-year-old woman who underwent cadaveric renal transplantation in 1990. No lesion was observed in the allograft during the pre- and perioperative period or on early postoperative ultrasounds. No graft rejection occurred under a standard triple immunosuppressive therapy. Thirteen years later, during a routine ultrasonography, 2 solid masses were discovered in the allograft, both of them richly vascularized. She underwent allograft nephrectomy and the histologic findings revealed that one of the tumors was a chromophilic (type 1) papillary RCC (2.5 cm in diameter) and the other, an angiomyolipoma (1.5 cm). Microsatellite analysis of the allograft, as compared with the recipient peripheral blood leukocytes, demonstrated that the 2 tumors (1 malignant and 1 benign) were of donor origin. To our knowledge, this is the first report of de novo concurrent papillary RCC and angiomyolipoma in a renal allograft. Adult Angiomyolipoma/etiology/genetics/pathology Cadaver Carcinoma, Renal Cell/etiology/genetics/pathology Female Humans Kidney Neoplasms/etiology/genetics/pathology Kidney Transplantation/adverse effects Male Microsatellite Repeats Neoplasms, Multiple Primary Nephrectomy Postoperative Complications Reoperation Tissue Donors Dewey 616.07 137 Département de pathologie et immunologie 21F false 393 Analyse protéomique et Analyse génomique des maladies rénales 659 Human pathology 37 4 c9423cd6-4cef-411d-8da6-c15e63a6d085 Article (Accepted version) Restricted Moll S. Human Pathol2006, 37(4), 481.pdf 1208207 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin	Human pathology			2006	573	0

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