Psoriasis localization patterns in the Swiss Psoriasis Registry (SDNTT) over 11 years : an analysis by sex and age

Article Article scientifique Article Psoriasis localization patterns in the Swiss Psoriasis Registry (SDNTT) over 11 years : an analysis by sex and age eng 2024-10-01 author Birkenmaier Ion Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.,Faculty of Science, University of Zürich, Zurich, Switzerland. author Maul Lara Valeska Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.,Faculty of Medicine, University of Zürich, Zurich, Switzerland. author Oyanguren Iker Swiss4ward, Statistician and Data Analyst, Zurich, Switzerland. author Sorbe Christina Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. author Fröhlich Fabienne Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.,Faculty of Medicine, University of Zürich, Zurich, Switzerland. author Schlapbach Christoph Department of Dermatology, Inselspital, University Hospital Bern, Bern, Switzerland. author Heidemeyer Kristine Department of Dermatology, Inselspital, University Hospital Bern, Bern, Switzerland. author Yawalkar Nikhil Department of Dermatology, Inselspital, University Hospital Bern, Bern, Switzerland. author Boehncke Wolf-Henning Division of Dermatology and Venereology, Geneva University Hospitals, Geneva, Switzerland. 779122 Département de médecine (DEMED) author Ring Hans-Christian Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. author Thyssen Jacob P Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.,Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. author Egeberg Alexander Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.,Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. author Micheroli Raphael Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. author Thomsen Simon Francis Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.,Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. author Mainetti Carlo Alfredo Department of Dermatology, Ente Ospedaliero Cantonale and Private Practice, Bellinzona, Switzerland. 519688 author Cozzio Antonio Department of Dermatology, Cantonal Hospital St, Gallen, St. Gallen, Switzerland. author Kündig Thomas M Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.,Faculty of Medicine, University of Zürich, Zurich, Switzerland. author Levesque Mitchell P Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.,Faculty of Medicine, University of Zürich, Zurich, Switzerland. author Navarini Alexander Department of Dermatology, University Hospital Basel, Basel, Switzerland.,Department of Biomedical Research, University of Basel, 4123, Allschwil, Switzerland. author Maul Julia-Tatjana Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland. julia-tatjana.maul@usz.ch.,Faculty of Medicine, University of Zürich, Zurich, Switzerland. julia-tatjana.maul@usz.ch. 654 10.1007/s00403-024-03375-5 39352439 0340-3696 PMC11445309 https://link.springer.com/10.1007/s00403-024-03375-5 Real-world data on anatomically localized psoriasis and its response to systemic therapy across different age-groups and sexes is limited. This study aimed to evaluate the severity and distribution of psoriasis over time in female and male patients receiving systemic therapies, categorized by age within the Swiss psoriasis registry (SDNTT). Patient-data was obtained over 11 years through the SDNTT. The localized Psoriasis Area and Severity Index (locPASI) of the head, trunk, upper and lower extremities was analyzed over two years following the start of systemic non-/biologic treatment. A total of 316 female and 517 male patients were analyzed. Male patients had a higher baseline locPASI for legs, trunk and arms (p < 0.001), but not for the head (p = 0.961). The locPASI for the head in younger female patients (18-40 years) had a higher score than those aged 55 + (p = 0.022) and after two years, middle aged (41-54) showed a lower score compared to younger patients (p = 0.045). Younger male patients revealed a lower score after two years of therapy in the leg- and arm-area compared to older (p = 0.018 and p = 0.048, respectively). Female patients on non-biologics had a fast initial response, converging with male patients' scores over 24 months. Over 75% locPASI reduction was observed for female head-area (81.4%), male trunk (82.7%) and legs (76.1%). Absolute locPASI ≤ 2 was achieved 3-6 months for all locations with interleukin (IL)-17, IL-12/23 and IL-23-inhibitors, except for the legs of male patients on anti-IL-17 and female patients on anti-IL-12/23 and -IL-23. After two years, male patients did not achieve a locPASI ≤ 2 for any biologic-treatment in the legs, nor for the arms on anti-TNF-α. Significant disparities in localized PASI were observed between female and male patients. The age, sex and severity of distinct localizations should be considered to optimize treatment goals. Biologics Localization Psoriasis Psoriasis area severity index Psoriasis treatment Registry data SDNTT Sex differences Dewey 616 56 Département de médecine 221 false 576 Inflammation cutanée 919 Archives of dermatological research 316 9 e73a98a7-7533-43b3-ab80-a176beb972cc Article (Published version) Public Article_scientifique_from_crossref.pdf 1120109 application/pdf CC BY-4.0 b7f117e9a441c7c94f3a69e2bb0d6ce9b879edd08e986ebbb2f798c04a686c81 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Psoriasis localization patterns in the Swiss Psoriasis Registry (SDNTT) over 11 years : an analysis by sex and age	Archives of dermatological research	2024	39	90
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Mainetti, Carlo Alfredo